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Cellosaurus Huh-7-Lunet (CVCL_U459)

[Text version]
Cell line name Huh-7-Lunet
Synonyms Huh-7 Lunet; Huh-7/Lunet; Huh7-Lunet; Huh7Lunet; Huh7L; Huh-7-Luc-Neo-ET
Accession CVCL_U459
Resource Identification Initiative To cite this cell line use: Huh-7-Lunet (RRID:CVCL_U459)
Comments Population: Japanese.
Transfected with: UniProtKB; P08659; Firefly luciferase.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; 6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
CVCL_CW91 (Huh-7-Lunet/Con1)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line

PubMed=15596831; DOI=10.1128/JVI.79.1.380-392.2005
Friebe P., Boudet J., Simorre J.-P., Bartenschlager R.F.W.
Kissing-loop interaction in the 3' end of the hepatitis C virus genome essential for RNA replication.
J. Virol. 79:380-392(2005)

PubMed=17079281; DOI=10.1128/JVI.01534-06
Koutsoudakis G., Herrmann E., Kallis S., Bartenschlager R.F.W., Pietschmann T.
The level of CD81 cell surface expression is a key determinant for productive entry of hepatitis C virus into host cells.
J. Virol. 81:588-598(2007)

PubMed=17552027; DOI=10.3748/wjg.v13.i17.2442
Duverlie G., Wychowski C.
Cell culture systems for the hepatitis C virus.
World J. Gastroenterol. 13:2442-2445(2007)

Cell line databases/resources cancercelllines; CVCL_U459
Anatomy/cell type resources BTO; BTO:0005725
Encyclopedic resources Wikidata; Q54896854
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number16