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Cellosaurus EH-118MG (CVCL_T447)

[Text version]
Cell line name EH-118MG
Synonyms EH118MG; 118 MG-EH; KC; KC-R; KC RAND
Accession CVCL_T447
Secondary accession CVCL_S097
Resource Identification Initiative To cite this cell line use: EH-118MG (RRID:CVCL_T447)
Comments Problematic cell line: Contaminated. Parent cell line (U-118MG) has been shown to be a U-138MG derivative.
Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
Population: Caucasian.
Transformant: NCBI_TaxID; 11886; Rous sarcoma virus [Note=Strain Engelbreth-Holm; RSV-EH].
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0633 (U-118MG)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line

PubMed=4313504; DOI=10.1111/j.1699-0463.1968.tb03502.x
Ponten J., Macintyre E.H.
Long term culture of normal and neoplastic human glia.
Acta Pathol. Microbiol. Scand. 74:465-486(1968)

PubMed=4312117; DOI=10.1242/jcs.5.3.583
Macintyre E.H., Grimes R.A., Vatter A.E.
Cytology and growth characteristics of human tumour astrocytes transformed by Rous sarcoma virus.
J. Cell Sci. 5:583-602(1969)

PubMed=4337530; DOI=10.1111/j.1699-0463.1972.tb02176.x
Macintyre E.H., Ponten J., Vatter A.E.
The ultrastructure of human and murine astrocytes and of human fibroblasts in culture.
Acta Pathol. Microbiol. Scand. A. 80:267-283(1972)

PubMed=4343952; DOI=10.1038/newbio240187a0
Rand K.H., Long C.W.
Syncytial assay for the putative human C-type virus, RD-114, utilizing human cells transformed by Rous sarcoma virus.
Nature New Biol. 240:187-190(1972)

PubMed=4351391; DOI=10.1093/jnci/50.5.1129
Nelson-Rees W.A., Klement V., Peterson W.D. Jr., Weaver J.F.
Comparative study of two RD 114 virus-indicator cell lines, KC and KB.
J. Natl. Cancer Inst. 50:1129-1135(1973)

PubMed=6500159; DOI=10.1159/000163283
Gershwin M.E., Lentz D., Owens R.B.
Relationship between karyotype of tissue culture lines and tumorigenicity in nude mice.
Exp. Cell Biol. 52:361-370(1984)

Cell line collections (Providers) ATCC; CRL-7719 - Discontinued
Cell line databases/resources cancercelllines; CVCL_T447
Encyclopedic resources Wikidata; Q54832099
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number18