ID   EH-118MG
AC   CVCL_T447
AS   CVCL_S097
SY   EH118MG; 118 MG-EH; KC; KC-R; KC RAND
DR   ATCC; CRL-7719
DR   cancercelllines; CVCL_T447
DR   Wikidata; Q54832099
RX   PubMed=4312117;
RX   PubMed=4313504;
RX   PubMed=4337530;
RX   PubMed=4343952;
RX   PubMed=4351391;
RX   PubMed=6500159;
CC   Problematic cell line: Contaminated. Parent cell line (U-118MG) has been shown to be a U-138MG derivative.
CC   Part of: Naval Biosciences Laboratory (NBL) collection (transferred to ATCC in 1982).
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
CC   Transformant: NCBI_TaxID; 11886; Rous sarcoma virus [Note=Strain Engelbreth-Holm; RSV-EH].
CC   Discontinued: ATCC; CRL-7719; true.
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0633 ! U-118MG
SX   Male
AG   47Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 18
RX   PubMed=4312117; DOI=10.1242/jcs.5.3.583;
RA   Macintyre E.H., Grimes R.A., Vatter A.E.;
RT   "Cytology and growth characteristics of human tumour astrocytes
RT   transformed by Rous sarcoma virus.";
RL   J. Cell Sci. 5:583-602(1969).
RX   PubMed=4313504; DOI=10.1111/j.1699-0463.1968.tb03502.x;
RA   Ponten J., Macintyre E.H.;
RT   "Long term culture of normal and neoplastic human glia.";
RL   Acta Pathol. Microbiol. Scand. 74:465-486(1968).
RX   PubMed=4337530; DOI=10.1111/j.1699-0463.1972.tb02176.x;
RA   Macintyre E.H., Ponten J., Vatter A.E.;
RT   "The ultrastructure of human and murine astrocytes and of human
RT   fibroblasts in culture.";
RL   Acta Pathol. Microbiol. Scand. A. 80:267-283(1972).
RX   PubMed=4343952; DOI=10.1038/newbio240187a0;
RA   Rand K.H., Long C.W.;
RT   "Syncytial assay for the putative human C-type virus, RD-114,
RT   utilizing human cells transformed by Rous sarcoma virus.";
RL   Nature New Biol. 240:187-190(1972).
RX   PubMed=4351391; DOI=10.1093/jnci/50.5.1129;
RA   Nelson-Rees W.A., Klement V., Peterson W.D. Jr., Weaver J.F.;
RT   "Comparative study of two RD 114 virus-indicator cell lines, KC and
RT   KB.";
RL   J. Natl. Cancer Inst. 50:1129-1135(1973).
RX   PubMed=6500159; DOI=10.1159/000163283;
RA   Gershwin M.E., Lentz D., Owens R.B.;
RT   "Relationship between karyotype of tissue culture lines and
RT   tumorigenicity in nude mice.";
RL   Exp. Cell Biol. 52:361-370(1984).