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Cellosaurus V-1181N1 (CVCL_T435)

[Text version]
Cell line name V-1181N1
Accession CVCL_T435
Resource Identification Initiative To cite this cell line use: V-1181N1 (RRID:CVCL_T435)
Comments Problematic cell line: Contaminated. Grand-parent cell line (U-118MG) has been shown to be a U-138MG derivative.
Population: Caucasian.
Virology: Infected with maedi visna virus (MVV).
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
Disease Astrocytoma (NCIt: C60781)
Astrocytoma (ORDO: Orphanet_94)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_D317 (1181N1)
Sex of cell Male
Age at sampling 47Y
Category Cancer cell line

Macintyre E.H., Wintersgill C.J., Thormar H.
The establishment of a line of visna virus-producing human astrocytes (V-1181N1).
Med. Res. Eng. 11:7-13(1972)

PubMed=4354152; DOI=10.1242/jcs.13.1.173
Macintyre E.H., Wintersgill C.J., Vatter A.E.
Visna virus infection of sheep and human cells in vitro -- an ultrastructural study.
J. Cell Sci. 13:173-191(1973)

Cell line databases/resources cancercelllines; CVCL_T435
Encyclopedic resources Wikidata; Q54992444
Entry history
Entry creation03-Feb-2014
Last entry update05-Oct-2023
Version number16