ID   V-1181N1
AC   CVCL_T435
DR   Wikidata; Q54992444
RX   PubMed=4354152;
RX   PubMed=4370460;
CC   Problematic cell line: Contaminated. Grand-parent cell line (U-118MG) has been shown to be a U-138MG derivative.
CC   Population: Caucasian.
CC   Virology: Infected with maedi visna virus (MVV).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.1026+1G>T (IVS8+1G>T); ClinVar=VCV000635377; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg213Gln (c.638G>A); ClinVar=VCV000135359; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Brain; UBERON=UBERON_0000955.
DI   NCIt; C60781; Astrocytoma
DI   ORDO; Orphanet_94; Astrocytoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_D317 ! 1181N1
SX   Male
AG   47Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 29-06-23; Version: 15
RX   PubMed=4354152; DOI=10.1242/jcs.13.1.173;
RA   Macintyre E.H., Wintersgill C.J., Vatter A.E.;
RT   "Visna virus infection of sheep and human cells in vitro -- an
RT   ultrastructural study.";
RL   J. Cell Sci. 13:173-191(1973).
RX   PubMed=4370460;
RA   Macintyre E.H., Wintersgill C.J., Thormar H.;
RT   "The establishment of a line of visna virus-producing human astrocytes
RT   (V-1181N1).";
RL   Med. Res. Eng. 11:7-13(1972).