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Cellosaurus HAC15 (CVCL_S898)

[Text version]
Cell line name HAC15
Synonyms HAC-15; HAC clone 15
Accession CVCL_S898
Resource Identification Initiative To cite this cell line use: HAC15 (RRID:CVCL_S898)
Comments Problematic cell line: Contaminated. Shown to be a NCI-H295R derivative (PubMed=21924324). Originally thought to originate from a 11 month old female patient with adrenal cortex carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00518.
Characteristics: Exhibits hormonal responses, steroidogenesis and expression of steroid-metabolizing enzymes.
Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
Sequence variations
  • Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Heterozygous (from parent cell line).
Disease Adrenal cortex carcinoma (NCIt: C9325)
Adrenocortical carcinoma (ORDO: Orphanet_1501)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0458 (NCI-H295R)
Sex of cell Female
Age at sampling 48Y
Category Cancer cell line
STR profile Source(s): ATCC=CRL-3301

Markers:
AmelogeninX
CSF1PO10,12
D5S81812
D7S8209,12
D13S31713
D16S53911
TH019.3
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=18713819; DOI=10.1210/jc.2008-0903
Parmar J., Key R.E., Rainey W.E.
Development of an adrenocorticotropin-responsive human adrenocortical carcinoma cell line.
J. Clin. Endocrinol. Metab. 93:4542-4546(2008)

PubMed=21924324; DOI=10.1016/j.mce.2011.08.041
Wang T., Rainey W.E.
Human adrenocortical carcinoma cell lines.
Mol. Cell. Endocrinol. 351:58-65(2012)

PubMed=22266826; DOI=10.1055/s-0031-1298019
Wang T., Rowland J.G., Parmar J., Nesterova M., Seki T., Rainey W.E.
Comparison of aldosterone production among human adrenocortical cell lines.
Horm. Metab. Res. 44:245-250(2012)

PubMed=35764904; DOI=10.1007/s12020-022-03112-w
Sigala S., Rossini E., Abate A., Tamburello M., Bornstein S.R., Hantel C.
An update on adrenocortical cell lines of human origin.
Endocrine 77:432-437(2022)

Cross-references
Cell line collections (Providers) ATCC; CRL-3301
Cell line databases/resources cancercelllines; CVCL_S898
Biological sample resources BioSample; SAMN06481111
Encyclopedic resources Wikidata; Q54872306
Entry history
Entry creation03-Feb-2014
Last entry update02-May-2024
Version number21