ID   HAC15
AC   CVCL_S898
SY   HAC-15; HAC clone 15
DR   ATCC; CRL-3301
DR   BioSample; SAMN06481111
DR   cancercelllines; CVCL_S898
DR   Wikidata; Q54872306
RX   PubMed=18713819;
RX   PubMed=21924324;
RX   PubMed=22266826;
RX   PubMed=35764904;
CC   Problematic cell line: Contaminated. Shown to be a NCI-H295R derivative (PubMed=21924324). Originally thought to originate from a 11 month old female patient with adrenal cortex carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00518.
CC   Characteristics: Exhibits hormonal responses, steroidogenesis and expression of steroid-metabolizing enzymes.
CC   Sequence variation: Mutation; HGNC; 2514; CTNNB1; Simple; p.Ser45Pro (c.133T>C); ClinVar=VCV000017589; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Adrenal gland; UBERON=UBERON_0002369.
ST   Source(s): ATCC=CRL-3301
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 13
ST   D16S539: 11
ST   D5S818: 12
ST   D7S820: 9,12
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C9325; Adrenal cortex carcinoma
DI   ORDO; Orphanet_1501; Adrenocortical carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0458 ! NCI-H295R
SX   Female
AG   48Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 02-05-24; Version: 21
RX   PubMed=18713819; DOI=10.1210/jc.2008-0903;
RA   Parmar J., Key R.E., Rainey W.E.;
RT   "Development of an adrenocorticotropin-responsive human adrenocortical
RT   carcinoma cell line.";
RL   J. Clin. Endocrinol. Metab. 93:4542-4546(2008).
RX   PubMed=21924324; DOI=10.1016/j.mce.2011.08.041;
RA   Wang T., Rainey W.E.;
RT   "Human adrenocortical carcinoma cell lines.";
RL   Mol. Cell. Endocrinol. 351:58-65(2012).
RX   PubMed=22266826; DOI=10.1055/s-0031-1298019;
RA   Wang T., Rowland J.G., Parmar J., Nesterova M., Seki T., Rainey W.E.;
RT   "Comparison of aldosterone production among human adrenocortical cell
RT   lines.";
RL   Horm. Metab. Res. 44:245-250(2012).
RX   PubMed=35764904; DOI=10.1007/s12020-022-03112-w;
RA   Sigala S., Rossini E., Abate A., Tamburello M., Bornstein S.R.,
RA   Hantel C.;
RT   "An update on adrenocortical cell lines of human origin.";
RL   Endocrine 77:432-437(2022).