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Cellosaurus MOLT-3/MTX10000 (CVCL_S658)

[Text version]
Cell line name MOLT-3/MTX10000
Synonyms MOLT-3/MTX10,000
Accession CVCL_S658
Resource Identification Initiative To cite this cell line use: MOLT-3/MTX10000 (RRID:CVCL_S658)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0624 (MOLT-3)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=3856477
Takao Ohnuma, Ruju Julia Lo, Kevin J. Scanlon, Barton Aaron Kamen, Taisuke Ohnoshi, Sandra R. Wolman, James Frederick Holland;
Evolution of methotrexate resistance of human acute lymphoblastic leukemia cells in vitro.
Cancer Res. 45:1815-1822(1985)

PubMed=8608962; DOI=10.1002/(SICI)1097-0215(19960328)66:1<29::AID-IJC6>3.0.CO;2-0
Yuzuru Takemura, Hiroyuki Kobayashi, William Gibson, Rosemary Kimbell, Hayato Miyachi, Ann L. Jackman;
The influence of drug-exposure conditions on the development of resistance to methotrexate or ZD1694 in cultured human leukaemia cells.
Int. J. Cancer 66:29-36(1996)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S658
Encyclopedic resources Wikidata; Q54906354
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number17