ID   MOLT-3/MTX10000
AC   CVCL_S658
SY   MOLT-3/MTX10,000
DR   Wikidata; Q54906354
RX   PubMed=3856477;
RX   PubMed=8608962;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
CC   Derived from sampling site: Peripheral blood. Cell type=T-cell.
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens
HI   CVCL_0624 ! MOLT-3
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 23-06-22; Version: 13
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RX   PubMed=3856477;
RA   Ohnuma T., Lo R.J., Scanlon K.J., Kamen B.A., Ohnoshi T., Wolman S.R.,
RA   Holland J.F.;
RT   "Evolution of methotrexate resistance of human acute lymphoblastic
RT   leukemia cells in vitro.";
RL   Cancer Res. 45:1815-1822(1985).
//
RX   PubMed=8608962; DOI=10.1002/(SICI)1097-0215(19960328)66:1<29::AID-IJC6>3.0.CO;2-0;
RA   Takemura Y., Kobayashi H., Gibson W., Kimbell R., Miyachi H.,
RA   Jackman A.L.;
RT   "The influence of drug-exposure conditions on the development of
RT   resistance to methotrexate or ZD1694 in cultured human leukaemia
RT   cells.";
RL   Int. J. Cancer 66:29-36(1996).
//