ID   MOLT-3/MTX10000
AC   CVCL_S658
SY   MOLT-3/MTX10,000
DR   cancercelllines; CVCL_S658
DR   Wikidata; Q54906354
RX   PubMed=3856477;
RX   PubMed=8608962;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0624 ! MOLT-3
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 17
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RX   PubMed=8608962; DOI=10.1002/(SICI)1097-0215(19960328)66:1<29::AID-IJC6>3.0.CO;2-0;
RA   Takemura, Yuzuru
RA   Kobayashi, Hiroyuki
RA   Gibson, William
RA   Kimbell, Rosemary
RA   Miyachi, Hayato
RA   Jackman, Ann L.
RT   "The influence of drug-exposure conditions on the development of
RT   resistance to methotrexate or ZD1694 in cultured human leukaemia
RT   cells.";
RL   Int. J. Cancer 66:29-36(1996).
//
RX   PubMed=3856477;
RA   Ohnuma, Takao
RA   Lo, Ruju Julia
RA   Scanlon, Kevin J.
RA   Kamen, Barton Aaron
RA   Ohnoshi, Taisuke
RA   Wolman, Sandra R.
RA   Holland, James Frederick
RT   "Evolution of methotrexate resistance of human acute lymphoblastic
RT   leukemia cells in vitro.";
RL   Cancer Res. 45:1815-1822(1985).
//