Cellosaurus cell line MOLT-3/TMQ200 (CVCL

Cellosaurus MOLT-3/TMQ200 (CVCL_S653)

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Cell line name

MOLT-3/TMQ200

Accession

CVCL_S653

Resource Identification Initiative

To cite this cell line use: MOLT-3/TMQ200 (RRID:CVCL_S653)

Comments

Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_9737; Trimetrexate.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.

Sequence variations

Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).

Disease

Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)

Species of origin

Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy

Parent: CVCL_0624 (MOLT-3)
Children:

CVCL_S654 (MOLT-3/TMQ200-CB371730)

CVCL_S657 (MOLT-3/TMQ200-MTX500)

Sex of cell

Male

Age at sampling

19Y