Cellosaurus logo
expasy logo

Cellosaurus MOLT-3/TMQ200-MTX500 (CVCL_S657)

[Text][XML][JSON]
Cell line name MOLT-3/TMQ200-MTX500
Accession CVCL_S657
Resource Identification Initiative To cite this cell line use: MOLT-3/TMQ200-MTX500 (RRID:CVCL_S657)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Selected for resistance to: ChEBI; CHEBI_9737; Trimetrexate.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S653 (MOLT-3/TMQ200)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=7850779; DOI=10.1016/0304-3835(94)03616-Q
Hayato Miyachi, Yuzuru Takemura, Hiroyuki Kobayashi, Yoshinari Ando;
Expression of variant dihydrofolate reductase with decreased binding affinity to antifolates in MOLT-3 human leukemia cell lines resistant to trimetrexate.
Cancer Lett. 88:93-99(1995)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S657
Encyclopedic resources Wikidata; Q54906359
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number17