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Cellosaurus MOLT-3/MTXt (CVCL_S652)

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Cell line name MOLT-3/MTXt
Accession CVCL_S652
Resource Identification Initiative To cite this cell line use: MOLT-3/MTXt (RRID:CVCL_S652)
Comments Population: Caucasian.
Doubling time: ~36 hours (PubMed=6978176).
Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0624 (MOLT-3)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=6978176
Taisuke Ohnoshi, Takao Ohnuma, Isao Takahashi, Kevin J. Scanlon, Barton Aaron Kamen, James Frederick Holland;
Establishment of methotrexate-resistant human acute lymphoblastic leukemia cells in culture and effects of folate antagonists.
Cancer Res. 42:1655-1660(1982)

Cross-references
Cell line databases/resources cancercelllines; CVCL_S652
Encyclopedic resources Wikidata; Q54906356
Entry history
Entry creation03-Feb-2014
Last entry update27-Nov-2025
Version number18