ID MOLT-3/MTXt AC CVCL_S652 DR cancercelllines; CVCL_S652 DR Wikidata; Q54906356 RX PubMed=6978176; CC Population: Caucasian. CC Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX). CC Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line). CC Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line). CC Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. CC Cell type: T-cell; CL=CL_0000084. DI NCIt; C9142; Adult T acute lymphoblastic leukemia DI ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia OX NCBI_TaxID=9606; ! Homo sapiens (Human) HI CVCL_0624 ! MOLT-3 SX Male AG 19Y CA Cancer cell line DT Created: 03-02-14; Last updated: 19-12-24; Version: 17 // RX PubMed=6978176; RA Ohnoshi T., Ohnuma T., Takahashi I., Scanlon K.J., Kamen B.A., RA Holland J.F.; RT "Establishment of methotrexate-resistant human acute lymphoblastic RT leukemia cells in culture and effects of folate antagonists."; RL Cancer Res. 42:1655-1660(1982). //