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Cellosaurus PLHC-1/dox (CVCL_S585)

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Cell line name PLHC-1/dox
Accession CVCL_S585
Resource Identification Initiative To cite this cell line use: PLHC-1/dox (RRID:CVCL_S585)
Comments Group: Fish cell line.
Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
Transformant: ChEBI; CHEBI_254496; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene).
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Disease Poeciliopsis lucida hepatocellular carcinoma (NCIt: C134962)
Species of origin Poeciliopsis lucida (Desert topminnow) (NCBI Taxonomy: 56613)
Hierarchy Parent: CVCL_3466 (PLHC-1)
Sex of cell Female
Age at sampling Adult
Category Cancer cell line
Publications

PubMed=18950875; DOI=10.1016/j.aquatox.2008.08.013
Daniel Caminada, Roko Zaja, Tvrtko Smital, Karl Fent;
Human pharmaceuticals modulate P-gp1 (ABCB1) transport activity in the fish cell line PLHC-1.
Aquat. Toxicol. 90:214-222(2008)

PubMed=21392495; DOI=10.1016/j.aquatox.2011.02.005
Roko Zaja, Jovica Loncar, Marta Popovic, Tvrtko Smital;
First characterization of fish P-glycoprotein (abcb1) substrate specificity using determinations of its ATPase activity and calcein-AM assay with PLHC-1/dox cell line.
Aquat. Toxicol. 103:53-62(2011)

Cross-references
Anatomy/cell type resources BTO; BTO_0005429
Encyclopedic resources Wikidata; Q54947579
Entry history
Entry creation03-Feb-2014
Last entry update19-Dec-2024
Version number13