ID   PLHC-1/dox
AC   CVCL_S585
DR   BTO; BTO_0005429
DR   Wikidata; Q54947579
RX   PubMed=18950875;
RX   PubMed=21392495;
CC   Group: Fish cell line.
CC   Selected for resistance to: ChEBI; CHEBI_28748; Doxorubicin (Adriablastin; Adriamycin).
CC   Transformant: ChEBI; CHEBI_254496; 7,12-dimethyltetraphene (DMBA; dimethylbenzanthracene).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C134962; Poeciliopsis lucida hepatocellular carcinoma
OX   NCBI_TaxID=56613; ! Poeciliopsis lucida (Desert topminnow)
HI   CVCL_3466 ! PLHC-1
SX   Female
AG   Adult
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 13
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RX   PubMed=18950875; DOI=10.1016/j.aquatox.2008.08.013;
RA   Caminada, Daniel
RA   Zaja, Roko
RA   Smital, Tvrtko
RA   Fent, Karl
RT   "Human pharmaceuticals modulate P-gp1 (ABCB1) transport activity in
RT   the fish cell line PLHC-1.";
RL   Aquat. Toxicol. 90:214-222(2008).
//
RX   PubMed=21392495; DOI=10.1016/j.aquatox.2011.02.005;
RA   Zaja, Roko
RA   Loncar, Jovica
RA   Popovic, Marta
RA   Smital, Tvrtko
RT   "First characterization of fish P-glycoprotein (abcb1) substrate
RT   specificity using determinations of its ATPase activity and
RT   calcein-AM assay with PLHC-1/dox cell line.";
RL   Aquat. Toxicol. 103:53-62(2011).
//