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Cellosaurus AGE1.CR (CVCL_S509)

[Text version]
Cell line name AGE1.CR
Synonyms CR; CR.HS; 17A02 clone H
Accession CVCL_S509
Resource Identification Initiative To cite this cell line use: AGE1.CR (RRID:CVCL_S509)
Comments Group: Bird cell line.
Group: Serum/protein free medium cell line.
Group: Vaccine production cell line.
From: ProBioGen AG; Berlin; Germany.
Doubling time: 23 hours (PubMed=19531390).
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5 (Note=E1A/E1B).
Derived from site: In situ; Fetal eye, retina; UBERON=UBERON_0003072.
Species of origin Cairina moschata (Muscovy duck) (NCBI Taxonomy: 8855)
Breed/subspecies: ST4 compact; VBO=VBO_0017525.
Hierarchy Children:
CVCL_S508 (AGE1.CR.pIX)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Transformed cell line
Web pages Provider; ProBioGen; -; https://www.probiogen.de/virus-production-cell-lines.html
Publications

Patent=WO2009156155A1
Volker Sandig, Ingo Jordan;
Cell line for propagation of highly attenuated alphaviruses.
Patent number WO2009156155A1, 30-Dec-2009

PubMed=19071186; DOI=10.1016/j.vaccine.2008.11.066
Ingo Jordan, Ad Vos, Stefanie Beilfuss, Andreas Neubert, Sabine Breul, Volker Sandig;
An avian cell line designed for production of highly attenuated viruses.
Vaccine 27:748-756(2009)

PubMed=19531390; DOI=10.1016/j.vaccine.2009.05.083
Verena Lohr, Alexander Rath, Yvonne Genzel, Ingo Jordan, Volker Sandig, Udo Reichl;
New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation.
Vaccine 27:4975-4982(2009)

DOI=10.17169/refubium-4684
Christiane Ogorek;
Characterization of the N-glycosylation profile of the new avian cell line AGE1.CR and the modification of fucosylation.
Thesis PhD (2012); Freien Universitat Berlin; Berlin; Germany

PubMed=25903999; DOI=10.1002/biot.201400388
Yvonne Genzel;
Designing cell lines for viral vaccine production: where do we stand?
Biotechnol. J. 10:728-740(2015)

PubMed=26814192; DOI=10.1080/03079457.2016.1138280
Ingo Jordan, Katrin John, Kristin Howing, Verena Lohr, Zoltan Penzes, Erzsebet Gubucz-Sombor, Yan Fu, Peng Gao, Timm Harder, Zoltan Zadori, Volker Sandig;
Continuous cell lines from the Muscovy duck as potential replacement for primary cells in the production of avian vaccines.
Avian Pathol. 45:137-155(2016)

Cross-references
Cell line databases/resources FCS-free; 122-23-201-3-4-3
FCS-free; 234-23-478-1-4-12
Encyclopedic resources Wikidata; Q54748632
Entry history
Entry creation03-Feb-2014
Last entry update14-Aug-2025
Version number20