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Cellosaurus AGE1.CR.pIX (CVCL_S508)

[Text version]
Cell line name AGE1.CR.pIX
Synonyms CR.pIX; CR.MCX; 17A11 clone B
Accession CVCL_S508
Resource Identification Initiative To cite this cell line use: AGE1.CR.pIX (RRID:CVCL_S508)
Comments Group: Bird cell line.
Group: Patented cell line.
Group: Serum/protein free medium cell line.
Group: Vaccine production cell line.
From: ProBioGen AG; Berlin; Germany.
Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2749.
Virology: Permissive for a wide spectrum of animal and human viruses including influenza (broad strain spectrum), rabies virus, Newcastle disease virus (NDV), duck and goose parvovirus, egg drop syndrome virus (EDS), avian infectious bursal disease virus (IBDV), turkey rhinotracheitis virus (TRT), Marek's disease virus (MDV), vesicular stomatitis virus (VSV) and herpesvirus of turkey (HVT) (ProBioGen).
Doubling time: 35 hours (PubMed=19531390).
Genetic integration: Method=Transfection; Gene=UniProtKB; P03281; Human adenovirus C serotype 5 pIX.
Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5 (Note=E1A/E1B).
Derived from site: In situ; Fetal eye, retina; UBERON=UBERON_0003072.
Species of origin Cairina moschata (Muscovy duck) (NCBI Taxonomy: 8855)
Breed/subspecies: ST4 compact; VBO=VBO_0017525.
Hierarchy Parent: CVCL_S509 (AGE1.CR)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Transformed cell line
Web pages Provider; ProBioGen; -; https://www.probiogen.de/virus-production-cell-lines.html
Provider; ProBioGen; -; https://www.probiogen.de/virus-production-cell-lines.html?file=files/images/content/02%20technology/PDF/Factsheet%20AGE.1%202018.pdf
Publications

Patent=WO2009156155A1
Volker Sandig, Ingo Jordan;
Cell line for propagation of highly attenuated alphaviruses.
Patent number WO2009156155A1, 30-Dec-2009

PubMed=19071186; DOI=10.1016/j.vaccine.2008.11.066
Ingo Jordan, Ad Vos, Stefanie Beilfuss, Andreas Neubert, Sabine Breul, Volker Sandig;
An avian cell line designed for production of highly attenuated viruses.
Vaccine 27:748-756(2009)

PubMed=19531390; DOI=10.1016/j.vaccine.2009.05.083
Verena Lohr, Alexander Rath, Yvonne Genzel, Ingo Jordan, Volker Sandig, Udo Reichl;
New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation.
Vaccine 27:4975-4982(2009)

DOI=10.17169/refubium-4684
Christiane Ogorek;
Characterization of the N-glycosylation profile of the new avian cell line AGE1.CR and the modification of fucosylation.
Thesis PhD (2012); Freien Universitat Berlin; Berlin; Germany

PubMed=25077436; DOI=10.1186/1472-6750-14-72; PMCID=PMC4124504
Verena Lohr, Oliver Hadicke, Yvonne Genzel, Ingo Jordan, Heino Buntemeyer, Steffen Klamt, Udo Reichl;
The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis.
BMC Biotechnol. 14:72.1-72.14(2014)

PubMed=25903999; DOI=10.1002/biot.201400388
Yvonne Genzel;
Designing cell lines for viral vaccine production: where do we stand?
Biotechnol. J. 10:728-740(2015)

PubMed=26814192; DOI=10.1080/03079457.2016.1138280
Ingo Jordan, Katrin John, Kristin Howing, Verena Lohr, Zoltan Penzes, Erzsebet Gubucz-Sombor, Yan Fu, Peng Gao, Timm Harder, Zoltan Zadori, Volker Sandig;
Continuous cell lines from the Muscovy duck as potential replacement for primary cells in the production of avian vaccines.
Avian Pathol. 45:137-155(2016)

Cross-references
Cell line databases/resources FCS-free; 122-23-201-3-4-3
FCS-free; 234-23-478-1-4-12
Encyclopedic resources Wikidata; Q54748635
Entry history
Entry creation03-Feb-2014
Last entry update14-Aug-2025
Version number23