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Cellosaurus AGE1.CR.pIX (CVCL_S508)

[Text version]
Cell line name AGE1.CR.pIX
Synonyms CR.pIX; CR.MCX; 17A11 clone B
Accession CVCL_S508
Resource Identification Initiative To cite this cell line use: AGE1.CR.pIX (RRID:CVCL_S508)
Comments Group: Bird cell line.
Group: Patented cell line.
Group: Serum/protein free medium cell line.
Group: Vaccine production cell line.
From: ProBioGen AG; Berlin; Germany.
Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2749.
Virology: Permissive for a wide spectrum of animal and human viruses including influenza (broad strain spectrum), rabies virus, Newcastle disease virus (NDV), duck and goose parvovirus, egg drop syndrome virus (EDS), infectious bursal disease virus (IBDV), turkey rhinotracheitis virus (TRT), Marek's disease virus (MDV), vesicular stomatitis virus (VSV) and herpesvirus of turkey (HVT) (ProBioGen).
Doubling time: 35 hours (PubMed=19531390).
Transfected with: UniProtKB; P03281; Adenovirus 5 pIX.
Transformant: NCBI_TaxID; 28285; Adenovirus 5 [E1A/E1B].
Derived from site: In situ; Fetal eye, retina; UBERON=UBERON_0003072.
Species of origin Cairina moschata (Muscovy duck) (NCBI Taxonomy: 8855)
Breed/subspecies: ST4 compact.
Hierarchy Parent: CVCL_S509 (AGE1.CR)
Sex of cell Sex unspecified
Age at sampling Embryo
Category Transformed cell line
Web pages https://www.probiogen.de/virus-production-cell-lines.html

Sandig V., Jordan I.
Cell line for propagation of highly attenuated alphaviruses.
Patent number WO2009156155A1, 30-Dec-2009

PubMed=19071186; DOI=10.1016/j.vaccine.2008.11.066
Jordan I., Vos A., Beilfuss S., Neubert A., Breul S., Sandig V.
An avian cell line designed for production of highly attenuated viruses.
Vaccine 27:748-756(2009)

PubMed=19531390; DOI=10.1016/j.vaccine.2009.05.083
Lohr V., Rath A., Genzel Y., Jordan I., Sandig V., Reichl U.
New avian suspension cell lines provide production of influenza virus and MVA in serum-free media: studies on growth, metabolism and virus propagation.
Vaccine 27:4975-4982(2009)

Ogorek C.
Characterization of the N-glycosylation profile of the new avian cell line AGE1.CR and the modification of fucosylation.
Thesis PhD (2012), Freien Universitat Berlin, Germany

PubMed=25077436; DOI=10.1186/1472-6750-14-72
Lohr V., Hadicke O., Genzel Y., Jordan I., Buntemeyer H., Klamt S., Reichl U.
The avian cell line AGE1.CR.pIX characterized by metabolic flux analysis.
BMC Biotechnol. 14:72.1-72.14(2014)

PubMed=25903999; DOI=10.1002/biot.201400388
Genzel Y.
Designing cell lines for viral vaccine production: where do we stand?
Biotechnol. J. 10:728-740(2015)

PubMed=26814192; DOI=10.1080/03079457.2016.1138280
Jordan I., John K., Howing K., Lohr V., Penzes Z., Gubucz-Sombor E., Fu Y., Gao P., Harder T., Zadori Z., Sandig V.
Continuous cell lines from the Muscovy duck as potential replacement for primary cells in the production of avian vaccines.
Avian Pathol. 45:137-155(2016)

Cell line databases/resources FCS-free; 122-23-201-3-4-3
FCS-free; 234-23-478-1-4-12
Encyclopedic resources Wikidata; Q54748635
Entry history
Entry creation03-Feb-2014
Last entry update29-Jun-2023
Version number18