ID   AGE1.CR.pIX
AC   CVCL_S508
SY   CR.pIX; CR.MCX; 17A11 clone B
DR   FCS-free; 122-23-201-3-4-3
DR   FCS-free; 234-23-478-1-4-12
DR   Wikidata; Q54748635
RX   DOI=10.17169/refubium-4684;
RX   Patent=WO2009156155A1;
RX   PubMed=19071186;
RX   PubMed=19531390;
RX   PubMed=25077436;
RX   PubMed=25903999;
RX   PubMed=26814192;
WW   Provider; ProBioGen; -; https://www.probiogen.de/virus-production-cell-lines.html
WW   Provider; ProBioGen; -; https://www.probiogen.de/virus-production-cell-lines.html?file=files/images/content/02%20technology/PDF/Factsheet%20AGE.1%202018.pdf
CC   Group: Bird cell line.
CC   Group: Patented cell line.
CC   Group: Serum/protein free medium cell line.
CC   Group: Vaccine production cell line.
CC   From: ProBioGen AG; Berlin; Germany.
CC   Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2749.
CC   Virology: Permissive for a wide spectrum of animal and human viruses including influenza (broad strain spectrum), rabies virus, Newcastle disease virus (NDV), duck and goose parvovirus, egg drop syndrome virus (EDS), avian infectious bursal disease virus (IBDV), turkey rhinotracheitis virus (TRT), Marek's disease virus (MDV), vesicular stomatitis virus (VSV) and herpesvirus of turkey (HVT) (ProBioGen).
CC   Doubling time: 35 hours (PubMed=19531390).
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P03281; Human adenovirus C serotype 5 pIX.
CC   Transformant: NCBI_TaxID; 28285; Human adenovirus C serotype 5 (Note=E1A/E1B).
CC   Derived from site: In situ; Fetal eye, retina; UBERON=UBERON_0003072.
CC   Breed/subspecies: ST4 compact; VBO=VBO_0017525.
OX   NCBI_TaxID=8855; ! Cairina moschata (Muscovy duck)
HI   CVCL_S509 ! AGE1.CR
SX   Sex unspecified
AG   Embryo
CA   Transformed cell line
DT   Created: 03-02-14; Last updated: 14-08-25; Version: 23
//
RX   Patent=WO2009156155A1;
RA   Sandig, Volker
RA   Jordan, Ingo
RT   "Cell line for propagation of highly attenuated alphaviruses.";
RL   Patent number WO2009156155A1, 30-Dec-2009.
//
RX   PubMed=25077436; DOI=10.1186/1472-6750-14-72; PMCID=PMC4124504;
RA   Lohr, Verena
RA   Hadicke, Oliver
RA   Genzel, Yvonne
RA   Jordan, Ingo
RA   Buntemeyer, Heino
RA   Klamt, Steffen
RA   Reichl, Udo
RT   "The avian cell line AGE1.CR.pIX characterized by metabolic flux
RT   analysis.";
RL   BMC Biotechnol. 14:72.1-72.14(2014).
//
RX   DOI=10.17169/refubium-4684;
RA   Ogorek, Christiane
RT   "Characterization of the N-glycosylation profile of the new avian cell
RT   line AGE1.CR and the modification of fucosylation.";
RL   Thesis PhD (2012); Freien Universitat Berlin; Berlin; Germany.
//
RX   PubMed=25903999; DOI=10.1002/biot.201400388;
RA   Genzel, Yvonne
RT   "Designing cell lines for viral vaccine production: where do we
RT   stand?";
RL   Biotechnol. J. 10:728-740(2015).
//
RX   PubMed=19071186; DOI=10.1016/j.vaccine.2008.11.066;
RA   Jordan, Ingo
RA   Vos, Ad
RA   Beilfuss, Stefanie
RA   Neubert, Andreas
RA   Breul, Sabine
RA   Sandig, Volker
RT   "An avian cell line designed for production of highly attenuated
RT   viruses.";
RL   Vaccine 27:748-756(2009).
//
RX   PubMed=26814192; DOI=10.1080/03079457.2016.1138280;
RA   Jordan, Ingo
RA   John, Katrin
RA   Howing, Kristin
RA   Lohr, Verena
RA   Penzes, Zoltan
RA   Gubucz-Sombor, Erzsebet
RA   Fu, Yan
RA   Gao, Peng
RA   Harder, Timm
RA   Zadori, Zoltan
RA   Sandig, Volker
RT   "Continuous cell lines from the Muscovy duck as potential replacement
RT   for primary cells in the production of avian vaccines.";
RL   Avian Pathol. 45:137-155(2016).
//
RX   PubMed=19531390; DOI=10.1016/j.vaccine.2009.05.083;
RA   Lohr, Verena
RA   Rath, Alexander
RA   Genzel, Yvonne
RA   Jordan, Ingo
RA   Sandig, Volker
RA   Reichl, Udo
RT   "New avian suspension cell lines provide production of influenza virus
RT   and MVA in serum-free media: studies on growth, metabolism and virus
RT   propagation.";
RL   Vaccine 27:4975-4982(2009).
//