ID   AGE1.CR.pIX
AC   CVCL_S508
SY   CR.pIX; CR.MCX; 17A11 clone B
DR   FCS-free; 122-23-201-3-4-3
DR   FCS-free; 234-23-478-1-4-12
DR   Wikidata; Q54748635
RX   DOI=10.17169/refubium-4684;
RX   Patent=WO2009156155A1;
RX   PubMed=19071186;
RX   PubMed=19531390;
RX   PubMed=25077436;
RX   PubMed=25903999;
RX   PubMed=26814192;
WW   https://www.probiogen.de/virus-production-cell-lines.html
WW   https://www.probiogen.de/virus-production-cell-lines.html?file=files/images/content/02%20technology/PDF/Factsheet%20AGE.1%202018.pdf
CC   Group: Bird cell line.
CC   Group: Patented cell line.
CC   Group: Serum/protein free medium cell line.
CC   Group: Vaccine production cell line.
CC   From: ProBioGen AG; Berlin; Germany.
CC   Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2749.
CC   Virology: Permissive for a wide spectrum of animal and human viruses including influenza (broad strain spectrum), rabies virus, Newcastle disease virus (NDV), duck and goose parvovirus, egg drop syndrome virus (EDS), infectious bursal disease virus (IBDV), turkey rhinotracheitis virus (TRT), Marek's disease virus (MDV), vesicular stomatitis virus (VSV) and herpesvirus of turkey (HVT) (ProBioGen).
CC   Doubling time: 35 hours (PubMed=19531390).
CC   Transfected with: UniProtKB; P03281; Adenovirus 5 pIX.
CC   Transformant: NCBI_TaxID; 28285; Adenovirus 5 [Note=E1A/E1B].
CC   Derived from site: In situ; Fetal eye, retina; UBERON=UBERON_0003072.
CC   Breed/subspecies: ST4 compact.
OX   NCBI_TaxID=8855; ! Cairina moschata (Muscovy duck)
HI   CVCL_S509 ! AGE1.CR
SX   Sex unspecified
AG   Embryo
CA   Transformed cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 19
//
RX   DOI=10.17169/refubium-4684;
RA   Ogorek C.;
RT   "Characterization of the N-glycosylation profile of the new avian cell
RT   line AGE1.CR and the modification of fucosylation.";
RL   Thesis PhD (2012), Freien Universitat Berlin, Germany.
//
RX   Patent=WO2009156155A1;
RA   Sandig V., Jordan I.;
RT   "Cell line for propagation of highly attenuated alphaviruses.";
RL   Patent number WO2009156155A1, 30-Dec-2009.
//
RX   PubMed=19071186; DOI=10.1016/j.vaccine.2008.11.066;
RA   Jordan I., Vos A., Beilfuss S., Neubert A., Breul S., Sandig V.;
RT   "An avian cell line designed for production of highly attenuated
RT   viruses.";
RL   Vaccine 27:748-756(2009).
//
RX   PubMed=19531390; DOI=10.1016/j.vaccine.2009.05.083;
RA   Lohr V., Rath A., Genzel Y., Jordan I., Sandig V., Reichl U.;
RT   "New avian suspension cell lines provide production of influenza virus
RT   and MVA in serum-free media: studies on growth, metabolism and virus
RT   propagation.";
RL   Vaccine 27:4975-4982(2009).
//
RX   PubMed=25077436; DOI=10.1186/1472-6750-14-72;
RA   Lohr V., Hadicke O., Genzel Y., Jordan I., Buntemeyer H., Klamt S.,
RA   Reichl U.;
RT   "The avian cell line AGE1.CR.pIX characterized by metabolic flux
RT   analysis.";
RL   BMC Biotechnol. 14:72.1-72.14(2014).
//
RX   PubMed=25903999; DOI=10.1002/biot.201400388;
RA   Genzel Y.;
RT   "Designing cell lines for viral vaccine production: where do we
RT   stand?";
RL   Biotechnol. J. 10:728-740(2015).
//
RX   PubMed=26814192; DOI=10.1080/03079457.2016.1138280;
RA   Jordan I., John K., Howing K., Lohr V., Penzes Z., Gubucz-Sombor E.,
RA   Fu Y., Gao P., Harder T., Zadori Z., Sandig V.;
RT   "Continuous cell lines from the Muscovy duck as potential replacement
RT   for primary cells in the production of avian vaccines.";
RL   Avian Pathol. 45:137-155(2016).
//