| Cell line name |
Hep-G2 SimpleCell O-GalNAc |
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| Synonyms |
HepG2 SimpleCell; HepG2 SC; HepG2SC |
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| Accession |
CVCL_S027 |
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| Resource Identification Initiative |
To cite this cell line use: Hep-G2 SimpleCell O-GalNAc (RRID:CVCL_S027) |
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| Comments |
Population: Caucasian.
Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
Knockout cell: Method=ZFN; HGNC; HGNC:24338; C1GALT1C1.
Derived from site: In situ; Liver; UBERON=UBERON_0002107. |
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| Sequence variations |
- Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
|
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| Disease |
Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0027 (Hep-G2)
Children: |
| CVCL_EI11 (Hep-G2 SimpleCell O-GalNAc KI GalNAc-T3) | CVCL_EI09 (Hep-G2 SimpleCell O-GalNAc KO GalNAc-T1) | CVCL_EI10 (Hep-G2 SimpleCell O-GalNAc KO GalNAc-T2) |
|
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| Sex of cell |
Male |
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| Age at sampling |
15Y |
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| Category |
Cancer cell line |
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| Publications | PubMed=23584533; DOI=10.1038/emboj.2013.79; PMCID=PMC3655468
Catharina Steentoft, Sergey Y. Vakhrushev, Hiren Jitendra Joshi, Yun Kong, Malene Bech Vester-Christensen, Katrine Ter-Borch Gram Schjoldager, Kirstine Lavrsen, Sally Dabelsteen, Nis B. Pedersen, Lara Marcos-Silva, Ramneek Gupta ...Show all 17 authors... , Eric Paul Bennett, Ulla Mandel, Soren Brunak, Hans Heugh Wandall, Steven Bruce Levery, Henrik Clausen; Show fewer authors
Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.
EMBO J. 32:1478-1488(2013) PubMed=26566661; DOI=10.15252/embr.201540796; PMCID=PMC4693523
Katrine Ter-Borch Gram Schjoldager, Hiren Jitendra Joshi, Yun Kong, Christoffer K. Goth, Sarah Louise King, Hans Heugh Wandall, Eric Paul Bennett, Sergey Y. Vakhrushev, Henrik Clausen;
Deconstruction of O-glycosylation -- GalNAc-T isoforms direct distinct subsets of the O-glycoproteome.
EMBO Rep. 16:1713-1722(2015) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_S027
|
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| Encyclopedic resources |
Wikidata; Q54882782
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| Entry history |
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| Entry creation | 05-Nov-2013 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 21 |
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