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Cellosaurus Hep-G2 SimpleCell O-GalNAc KI GalNAc-T3 (CVCL_EI11)

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Cell line name Hep-G2 SimpleCell O-GalNAc KI GalNAc-T3
Synonyms HepG2SC+T3
Accession CVCL_EI11
Resource Identification Initiative To cite this cell line use: Hep-G2 SimpleCell O-GalNAc KI GalNAc-T3 (RRID:CVCL_EI11)
Comments Population: Caucasian.
Characteristics: Cell engineered to produce only truncated GalNAc or NeuAc-alpha-2-6-GalNAc O-glycans.
Knockout cell: Method=ZFN; HGNC; HGNC:24338; C1GALT1C1.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:24137; B4GALNT3.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Hepatoblastoma (NCIt: C3728)
Hepatoblastoma (ORDO: Orphanet_449)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_S027 (Hep-G2 SimpleCell O-GalNAc)
Sex of cell Male
Age at sampling 15Y
Category Cancer cell line
Publications

PubMed=26566661; DOI=10.15252/embr.201540796; PMCID=PMC4693523
Katrine Ter-Borch Gram Schjoldager, Hiren Jitendra Joshi, Yun Kong, Christoffer K. Goth, Sarah Louise King, Hans Heugh Wandall, Eric Paul Bennett, Sergey Y. Vakhrushev, Henrik Clausen;
Deconstruction of O-glycosylation -- GalNAc-T isoforms direct distinct subsets of the O-glycoproteome.
EMBO Rep. 16:1713-1722(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_EI11
Encyclopedic resources Wikidata; Q54882783
Proteomic databases PRIDE; PXD002770
Entry history
Entry creation13-Jul-2016
Last entry update19-Dec-2024
Version number17