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Cellosaurus CHO-AS52 Ogg1(-/-)-Mutyh(-/-) (CVCL_RM50)

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Cell line name CHO-AS52 Ogg1(-/-)-Mutyh(-/-)
Synonyms AS52 Ogg1-/-Mutyh-/-; OGG1-/-MUTYH-/- AS52
Accession CVCL_RM50
Resource Identification Initiative To cite this cell line use: CHO-AS52 Ogg1(-/-)-Mutyh(-/-) (RRID:CVCL_RM50)
Comments Knockout cell: Method=CRISPR/Cas9; UniProtKB; G3GX91; Ogg1.
Knockout cell: Method=CRISPR/Cas9; UniProtKB; G3GYQ5; Mutyh.
Genetic integration: Method=Transfection; Gene=UniProtKB; P0A9M5; Escherichia coli gpt.
Transformant: NCIt; C17262; X-Ray.
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_Y504 (CHO-AS52)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=29289706; DOI=10.1016/j.freeradbiomed.2017.12.035; PMCID=PMC5902796
Preechaya Tajai, Bogdan I. Fedeles, Tawit Suriyo, Panida Navasumrit, Jantamas Kanitwithayanun, John M. Essigmann, Jutamaad Satayavivad;
An engineered cell line lacking OGG1 and MUTYH glycosylases implicates the accumulation of genomic 8-oxoguanine as the basis for paraquat mutagenicity.
Free Radic. Biol. Med. 116:64-72(2018)

Cross-references
Encyclopedic resources Wikidata; Q54812640
Entry history
Entry creation05-Mar-2018
Last entry update19-Dec-2024
Version number10