ID   CHO-AS52 Ogg1(-/-)-Mutyh(-/-)
AC   CVCL_RM50
SY   AS52 Ogg1-/-Mutyh-/-; OGG1-/-MUTYH-/- AS52
DR   Wikidata; Q54812640
RX   PubMed=29289706;
CC   Knockout cell: Method=CRISPR/Cas9; UniProtKB; G3GX91; Ogg1.
CC   Knockout cell: Method=CRISPR/Cas9; UniProtKB; G3GYQ5; Mutyh.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P0A9M5; Escherichia coli gpt.
CC   Transformant: NCIt; C17262; X-Ray.
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_Y504 ! CHO-AS52
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 05-03-18; Last updated: 19-12-24; Version: 10
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RX   PubMed=29289706; DOI=10.1016/j.freeradbiomed.2017.12.035; PMCID=PMC5902796;
RA   Tajai P., Fedeles B.I., Suriyo T., Navasumrit P., Kanitwithayanun J.,
RA   Essigmann J.M., Satayavivad J.;
RT   "An engineered cell line lacking OGG1 and MUTYH glycosylases
RT   implicates the accumulation of genomic 8-oxoguanine as the basis for
RT   paraquat mutagenicity.";
RL   Free Radic. Biol. Med. 116:64-72(2018).
//