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Cellosaurus SUM159PT shPARG (CVCL_RA93)

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Cell line name SUM159PT shPARG
Synonyms shPARG SUM159
Accession CVCL_RA93
Resource Identification Initiative To cite this cell line use: SUM159PT shPARG (RRID:CVCL_RA93)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Knockout cell: Method=shRNA knockdown; HGNC; HGNC:8605; PARG.
Omics: Proteomics; PTM; Poly-ADP-ribosylation.
Derived from site: In situ; Breast; UBERON=UBERON_0000310.
Sequence variations
  • Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012612; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.His1047Leu (c.3140A>T); ClinVar=VCV000013653; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val157_Arg158insLeu (c.472_473ins3); Zygosity=Unspecified (from parent cell line).
Disease Breast pleomorphic carcinoma (NCIt: C5161)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_5423 (SUM159PT)
Sex of cell Female
Age at sampling 71Y
Category Cancer cell line
Publications

PubMed=29166620; DOI=10.1016/j.celrep.2017.10.106; PMCID=PMC5728415
Yuan-Li Zhen, Ya-Jie Zhang, Yong-Hao Yu;
A cell-line-specific atlas of PARP-mediated protein Asp/Glu-ADP-ribosylation in breast cancer.
Cell Rep. 21:2326-2337(2017)

Cross-references
Cell line databases/resources cancercelllines; CVCL_RA93
Encyclopedic resources Wikidata; Q54970842
Entry history
Entry creation05-Mar-2018
Last entry update10-Apr-2025
Version number12