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Cellosaurus MDA-MB-435-BAG (CVCL_R957)

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Cell line name MDA-MB-435-BAG
Synonyms MDA-MB-435 BAG
Accession CVCL_R957
Resource Identification Initiative To cite this cell line use: MDA-MB-435-BAG (RRID:CVCL_R957)
Comments Problematic cell line: Contaminated. Parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
Population: Caucasian.
Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0417 (MDA-MB-435)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
Publications

PubMed=1384607; DOI=10.1016/0959-8049(92)90245-W
Nils Brunner, Erik W. Thompson, Mogens Spang-Thomsen, Jergen Rygaard, Keld Dano, James A. Zwiebel;
lacZ transduced human breast cancer xenografts as an in vivo model for the study of invasion and metastasis.
Eur. J. Cancer 28A:1989-1995(1992)

Cross-references
Cell line databases/resources cancercelllines; CVCL_R957
Encyclopedic resources Wikidata; Q54904633
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number24