ID   MDA-MB-435-BAG
AC   CVCL_R957
SY   MDA-MB-435 BAG
DR   cancercelllines; CVCL_R957
DR   Wikidata; Q54904633
RX   PubMed=1384607;
CC   Problematic cell line: Contaminated. Parent cell line (MDA-MB-435) has been shown to be a M14 derivative.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P00722; Escherichia coli beta-galactosidase (lacZ).
CC   Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0417 ! MDA-MB-435
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 19-12-24; Version: 24
//
RX   PubMed=1384607; DOI=10.1016/0959-8049(92)90245-W;
RA   Brunner, Nils
RA   Thompson, Erik W.
RA   Spang-Thomsen, Mogens
RA   Rygaard, Jergen
RA   Dano, Keld
RA   Zwiebel, James A.
RT   "lacZ transduced human breast cancer xenografts as an in vivo model
RT   for the study of invasion and metastasis.";
RL   Eur. J. Cancer 28A:1989-1995(1992).
//