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Cellosaurus KMST-6/RAS (CVCL_M810)

[Text version]
Cell line name KMST-6/RAS
Synonyms KMST-6-Ras
Accession CVCL_M810
Resource Identification Initiative To cite this cell line use: KMST-6/RAS (RRID:CVCL_M810)
Comments Population: Japanese.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gln61Leu).
Transformant: NCIt; C129640; Cobalt-60 gamma radiation.
Derived from site: In situ; Whole fetus; UBERON=UBERON_0000323.
Cell type: Fibroblast; CL=CL_0000057.
Sequence variations
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Pro (c.536A>C); ClinVar=VCV000376611; Zygosity=Heterozygous (from parent cell line).
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_2998 (KMST-6)
Sex of cell Female
Age at sampling 9FW
Category Transformed cell line
Publications

PubMed=3140712
Masayoshi Namba, Koji Nishitani, Fujiko Fukushima, Tetsuo Kimoto;
Multistep carcinogenesis of normal human fibroblasts. Human fibroblasts immortalized by repeated treatment with Co-60 gamma rays were transformed into tumorigenic cells with Ha-ras oncogenes.
Anticancer Res. 8:947-958(1988)

DOI=10.11418/jtca1981.12.4_313
Masayoshi Namba, Li-Yan Bai, Yoshio Kano, Shigetaka Sugihara, Masahiro Miyazaki;
Multistep malignant transformation of human cells: immortalization of human fibroblasts by treatment with 60Co gamma rays and 4-nitroquinoline 1-oxide, and their malignant transformation with the ras oncogene.
Tissue Cult. Res. Commun. 12:313-318(1993)

PubMed=8118610; DOI=10.1007/BF02634342
Israt Jahan, Koichiro Mihara, Li-Yan Bai, Masayoshi Namba;
Neoplastic transformation and characterization of human fibroblasts by treatment with 60Co gamma rays and the human c-Ha-ras oncogene.
In Vitro Cell. Dev. Biol. Anim. 29:763-767(1993)

PubMed=8148305
Masayoshi Namba, Mikio Iijima, Tadashi Kondo, Israt Jahan, Koichiro Mihara;
Immortalization of normal human cells is a multistep process and a rate limiting step of neoplastic transformation of the cells.
Hum. Cell 6:253-259(1993)

PubMed=7520808; DOI=10.1007/BF02632040
Kunihiro Kawashima, Masaharu Mori, Shouji Furusako, Hisashi Usuki, Nobuyoshi Shimizu, Masayoshi Namba;
Granulocyte-colony stimulating factor (G-CSF) production of human fibroblasts (KMST-6/RAS line) transformed with 60Co gamma rays and c-Ha-ras oncogene.
In Vitro Cell. Dev. Biol. Anim. 30:199-201(1994)

PubMed=7524638
Kunihiro Kawashima, Masaharu Mori, Shouji Furusako, Hisashi Usuki, Masayoshi Namba;
Human fibroblasts (KMST-6/RAS line) transformed with 60Co gamma-rays and c-Ha-ras oncogene constitutively produce a large amount of human granulocyte-colony stimulating factor (G-CSF).
Hum. Cell 7:88-94(1994)

PubMed=7540958; DOI=10.1247/csf.20.41
Kunihiro Kawashima, Israt Jahan, Kazuo Fushimi, Koichiro Mihara, Masayoshi Namba;
Human fibroblasts (KMST-6/RAS cell line) transformed with 60Co gamma-rays and c-Ha-ras oncogene produce a large amount of granulocyte colony-stimulating factor (G-CSF); production is enhanced by cAMP, theophylline, and butyrate.
Cell Struct. Funct. 20:41-45(1995)

PubMed=8601579; DOI=10.1007/BF01209654
Israt Jahan, Mikio Iijima, Tadashi Kondo, Masayoshi Namba;
Effects of okadaic acid on cell growth, anchorage-independent growth, and co-cultures of normal (KMS-6), immortalized (KMST-6), and neoplastically transformed (KMST-6T and KMST-6/RAS) human fibroblasts.
J. Cancer Res. Clin. Oncol. 122:249-253(1996)

PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D
Li-Qun Jia, Motonobu Osada, Chikashi Ishioka, Makio Gamo, Shuntaro Ikawa, Takao Suzuki, Hideki Shimodaira, Tomohito Niitani, Toshio Kudo, Mitoshi Akiyama, Narimiti Kimura ...Show all 18 authors... , Mitsuyoshi Matsuo, Hiroshi Mizusawa, Noriho Tanaka, Hideki Koyama, Masayoshi Namba, Ryunosuke Kanamaru, Toshio Kuroki; Show fewer authors
Screening the p53 status of human cell lines using a yeast functional assay.
Mol. Carcinog. 19:243-253(1997)

Cross-references
Encyclopedic resources Wikidata; Q54900190
Entry history
Entry creation05-Nov-2013
Last entry update14-Aug-2025
Version number21