ID   KMST-6/RAS
AC   CVCL_M810
SY   KMST-6-Ras
DR   Wikidata; Q54900190
RX   DOI=10.11418/jtca1981.12.4_313;
RX   PubMed=3140712;
RX   PubMed=7520808;
RX   PubMed=7524638;
RX   PubMed=8118610;
RX   PubMed=8148305;
RX   PubMed=8601579;
RX   PubMed=9290701;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His179Pro (c.536A>C); ClinVar=VCV000376611; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 5173; HRAS (with p.Gln61Leu).
CC   Transformant: NCIt; C129640; Cobalt-60 gamma radiation.
CC   Derived from site: In situ; Whole fetus; UBERON=UBERON_0000323.
CC   Cell type: Fibroblast; CL=CL_0000057.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2998 ! KMST-6
SX   Female
AG   9FW
CA   Transformed cell line
DT   Created: 05-11-13; Last updated: 29-06-23; Version: 18
//
RX   DOI=10.11418/jtca1981.12.4_313;
RA   Namba M., Bai L., Kano Y., Sugihara S., Miyazaki M.;
RT   "Multistep malignant transformation of human cells: immortalization of
RT   human fibroblasts by treatment with 60Co gamma rays and 4-nitroquinoline
RT   1-oxide, and their malignant transformation with the ras oncogene.";
RL   Tissue Cult. Res. Commun. 12:313-318(1993).
//
RX   PubMed=3140712;
RA   Namba M., Nishitani K., Fukushima F., Kimoto T.;
RT   "Multistep carcinogenesis of normal human fibroblasts. Human
RT   fibroblasts immortalized by repeated treatment with Co-60 gamma rays
RT   were transformed into tumorigenic cells with Ha-ras oncogenes.";
RL   Anticancer Res. 8:947-958(1988).
//
RX   PubMed=7520808; DOI=10.1007/BF02632040;
RA   Kawashima K., Mori M., Furusako S., Usuki H., Shimizu N., Namba M.;
RT   "Granulocyte-colony stimulating factor (G-CSF) production of human
RT   fibroblasts (KMST-6/RAS line) transformed with 60Co gamma rays and
RT   c-Ha-ras oncogene.";
RL   In Vitro Cell. Dev. Biol. Anim. 30:199-201(1994).
//
RX   PubMed=7524638;
RA   Kawashima K., Mori M., Furusako S., Usuki H., Namba M.;
RT   "Human fibroblasts (KMST-6/RAS line) transformed with 60Co gamma-rays
RT   and c-Ha-ras oncogene constitutively produce a large amount of human
RT   granulocyte-colony stimulating factor (G-CSF).";
RL   Hum. Cell 7:88-94(1994).
//
RX   PubMed=8118610; DOI=10.1007/BF02634342;
RA   Jahan I., Mihara K., Bai L., Namba M.;
RT   "Neoplastic transformation and characterization of human fibroblasts
RT   by treatment with 60Co gamma rays and the human c-Ha-ras oncogene.";
RL   In Vitro Cell. Dev. Biol. Anim. 29:763-767(1993).
//
RX   PubMed=8148305;
RA   Namba M., Iijima M., Kondo T., Jahan I., Mihara K.;
RT   "Immortalization of normal human cells is a multistep process and a
RT   rate limiting step of neoplastic transformation of the cells.";
RL   Hum. Cell 6:253-259(1993).
//
RX   PubMed=8601579; DOI=10.1007/BF01209654;
RA   Jahan I., Iijima M., Kondo T., Namba M.;
RT   "Effects of okadaic acid on cell growth, anchorage-independent growth,
RT   and co-cultures of normal (KMS-6), immortalized (KMST-6), and
RT   neoplastically transformed (KMST-6T and KMST-6/RAS) human
RT   fibroblasts.";
RL   J. Cancer Res. Clin. Oncol. 122:249-253(1996).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T.,
RA   Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M.,
RA   Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.;
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//