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Cellosaurus MOLT-3/Z29 (CVCL_M774)

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Cell line name MOLT-3/Z29
Synonyms Molt-3/Z29; Molt-3/Z-29; MOLT-3 / Z29
Accession CVCL_M774
Resource Identification Initiative To cite this cell line use: MOLT-3/Z29 (RRID:CVCL_M774)
Comments Population: Caucasian.
Virology: Infected by human herpesvirus 6B (HHV-6B) strain Z29.
Caution: Was discontinued from BEI_Resources because the cell line seemed to have also been infected by HIV-1 (personal communication of Rashid, Sujatha).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084.
Sequence variations
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
Disease Adult T acute lymphoblastic leukemia (NCIt: C9142)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0624 (MOLT-3)
Sex of cell Male
Age at sampling 19Y
Category Cancer cell line
Publications

PubMed=1653487; DOI=10.1016/0042-6822(91)90424-A
Dharam Vir Ablashi, N. Balachandran, Steven F. Josephs, Chia-Ling Hung, Gerhard R.F. Krueger, Bernhard Kramarsky, Syed Zaki Salahuddin, Robert Charles Gallo;
Genomic polymorphism, growth properties, and immunologic variations in human herpesvirus-6 isolates.
Virology 184:545-552(1991)

Cross-references
Cell line collections (Providers) BEI_Resources; ARP-12185 - Discontinued
Cell line databases/resources cancercelllines; CVCL_M774
Encyclopedic resources Wikidata; Q54906362
Entry history
Entry creation05-Nov-2013
Last entry update19-Dec-2024
Version number19