ID   MOLT-3/Z29
AC   CVCL_M774
SY   Molt-3/Z29; Molt-3/Z-29; MOLT-3 / Z29
DR   BEI_Resources; ARP-12185
DR   cancercelllines; CVCL_M774
DR   Wikidata; Q54906362
RX   PubMed=1653487;
CC   Population: Caucasian.
CC   Virology: Infected by human herpesvirus 6B (HHV-6B) strain Z29.
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1600Pro (c.4799T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2514Argfs*4 (c.7541_7542delCT); ClinVar=VCV000581973; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Lys267Argfs*9 (c.800delA) (p.Leu265fs, c.795delA); ClinVar=VCV000092828; Zygosity=Homozygous (from parent cell line).
CC   Caution: Was discontinued from BEI_Resources because the cell line seemed to have also been infected by HIV-1 (personal communication of Rashid, Sujatha).
CC   Discontinued: BEI_Resources; ARP-12185; true.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C9142; Adult T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0624 ! MOLT-3
SX   Male
AG   19Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 19-12-24; Version: 19
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RX   PubMed=1653487; DOI=10.1016/0042-6822(91)90424-A;
RA   Ablashi D.V., Balachandran N., Josephs S.F., Hung C.-L.,
RA   Krueger G.R.F., Kramarsky B., Salahuddin S.Z., Gallo R.C.;
RT   "Genomic polymorphism, growth properties, and immunologic variations
RT   in human herpesvirus-6 isolates.";
RL   Virology 184:545-552(1991).
//