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Cellosaurus 50B11 (CVCL_M745)

[Text version]
Cell line name 50B11
Accession CVCL_M745
Resource Identification Initiative To cite this cell line use: 50B11 (RRID:CVCL_M745)
Comments Characteristics: Differentiation into neurons with nociceptive properties can be accomplished by using forskolin (PubMed=17565537).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; B.cereus Bsr.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Dorsal root ganglion; UBERON=UBERON_0000044.
Cell type: Neuron; CL=CL_0000540.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Hierarchy Children:
CVCL_C1LC (50B11 clone D4W)CVCL_C1LD (50B11 clone E4)
Sex of cell Sex unspecified
Age at sampling 14-15FD
Category Transformed cell line
Publications

PubMed=17565537; DOI=10.1111/j.1529-8027.2007.00131.x; PMCID=PMC3417147
Chen W.-R., Mi R.-F., Haughey N., Oz M., Hoke A.
Immortalization and characterization of a nociceptive dorsal root ganglion sensory neuronal line.
J. Peripher. Nerv. Syst. 12:121-130(2007)

PubMed=24269872; DOI=10.1016/j.neulet.2013.11.018; PMCID=PMC3903183
Bhattacherjee A., Liao Z.-H., Smith P.G.
Trophic factor and hormonal regulation of neurite outgrowth in sensory neuron-like 50B11 cells.
Neurosci. Lett. 558:120-125(2014)

PubMed=32636736; DOI=10.3389/fncel.2020.00184; PMCID=PMC7319018
Haberberger R.V., Barry C.M., Matusica D.
Immortalized dorsal root ganglion neuron cell lines.
Front. Cell. Neurosci. 14:184.1-184.21(2020)

PubMed=33307981; DOI=10.1177/1744806920970368; PMCID=PMC7745567
Matusica D., Canlas J., Martin M.A., Wei Y.-K., Marri S., Erickson A., Barry C.M., Brierley S.M., Best O.G., Michael M.Z., Voelcker N.H., Keating D.J., Haberberger R.V.
Differentiation of the 50B11 dorsal root ganglion cells into NGF and GDNF responsive nociceptor subtypes.
Mol. Pain 16:1744806920970368.1-1744806920970368.20(2020)

PubMed=35782611; DOI=10.1016/j.ymgmr.2022.100871; PMCID=PMC9248215
Kaneski C.R., Hanover J.A., Schueler Hoffman U.H.
Generation of an in vitro model for peripheral neuropathy in Fabry disease using CRISPR-Cas9 in the nociceptive dorsal root ganglion cell line 50B11.
Mol. Genet. Metab. Rep. 31:100871.1-100871.8(2022)

Cross-references
Encyclopedic resources Wikidata; Q54603686
Gene expression databases GEO; GSE147186
Entry history
Entry creation05-Nov-2013
Last entry update10-Apr-2025
Version number13