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Cellosaurus 50B11 (CVCL_M745)

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Cell line name 50B11
Accession CVCL_M745
Resource Identification Initiative To cite this cell line use: 50B11 (RRID:CVCL_M745)
Comments Characteristics: Differentiation into neurons with nociceptive properties can be accomplished by using forskolin (PubMed=17565537).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; Bacillus cereus Bsr.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
Omics: Transcriptomics; RNAseq.
Derived from site: In situ; Dorsal root ganglion; UBERON=UBERON_0000044.
Cell type: Neuron; CL=CL_0000540.
Species of origin Rattus norvegicus (Rat) (NCBI Taxonomy: 10116)
Hierarchy Children:
CVCL_C1LC (50B11 clone D4W)CVCL_C1LD (50B11 clone E4)
Sex of cell Sex unspecified
Age at sampling 14-15FD
Category Transformed cell line
Publications

PubMed=17565537; DOI=10.1111/j.1529-8027.2007.00131.x; PMCID=PMC3417147
Wei-Ran Chen, Rui-Fa Mi, Norman Haughey, Murat Oz, Ahmet Hoke;
Immortalization and characterization of a nociceptive dorsal root ganglion sensory neuronal line.
J. Peripher. Nerv. Syst. 12:121-130(2007)

PubMed=24269872; DOI=10.1016/j.neulet.2013.11.018; PMCID=PMC3903183
Aritra Bhattacherjee, Zhao-Hui Liao, Peter G. Smith;
Trophic factor and hormonal regulation of neurite outgrowth in sensory neuron-like 50B11 cells.
Neurosci. Lett. 558:120-125(2014)

PubMed=32636736; DOI=10.3389/fncel.2020.00184; PMCID=PMC7319018
Rainer Viktor Haberberger, Christine M. Barry, Dusan Matusica;
Immortalized dorsal root ganglion neuron cell lines.
Front. Cell. Neurosci. 14:184.1-184.21(2020)

PubMed=33307981; DOI=10.1177/1744806920970368; PMCID=PMC7745567
Dusan Matusica, Jastrow Canlas, Alyce M. Martin, Ying-Kai Wei, Shashikanth Marri, Andelain Erickson, Christine M. Barry, Stuart M. Brierley, Oliver G. Best, Michael Z. Michael, Nicolas Hans Voelcker ...Show all 13 authors... , Damien J. Keating, Rainer Viktor Haberberger; Show fewer authors
Differentiation of the 50B11 dorsal root ganglion cells into NGF and GDNF responsive nociceptor subtypes.
Mol. Pain 16:1744806920970368.1-1744806920970368.20(2020)

PubMed=35782611; DOI=10.1016/j.ymgmr.2022.100871; PMCID=PMC9248215
Christine R. Kaneski, John A. Hanover, Ulrike H. Schueler Hoffman;
Generation of an in vitro model for peripheral neuropathy in Fabry disease using CRISPR-Cas9 in the nociceptive dorsal root ganglion cell line 50B11.
Mol. Genet. Metab. Rep. 31:100871.1-100871.8(2022)

Cross-references
Encyclopedic resources Wikidata; Q54603686
Gene expression databases GEO; GSE147186
Entry history
Entry creation05-Nov-2013
Last entry update14-Aug-2025
Version number14