ID   50B11
AC   CVCL_M745
DR   GEO; GSE147186
DR   Wikidata; Q54603686
RX   PubMed=17565537;
RX   PubMed=24269872;
RX   PubMed=32636736;
RX   PubMed=33307981;
RX   PubMed=35782611;
CC   Characteristics: Differentiation into neurons with nociceptive properties can be accomplished by using forskolin (PubMed=17565537).
CC   Genetic integration: Method=Transfection; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P33967; B.cereus Bsr.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Dorsal root ganglion; UBERON=UBERON_0000044.
CC   Cell type: Neuron; CL=CL_0000540.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Sex unspecified
AG   14-15FD
CA   Transformed cell line
DT   Created: 05-11-13; Last updated: 10-04-25; Version: 13
//
RX   PubMed=17565537; DOI=10.1111/j.1529-8027.2007.00131.x; PMCID=PMC3417147;
RA   Chen W.-R., Mi R.-F., Haughey N., Oz M., Hoke A.;
RT   "Immortalization and characterization of a nociceptive dorsal root
RT   ganglion sensory neuronal line.";
RL   J. Peripher. Nerv. Syst. 12:121-130(2007).
//
RX   PubMed=24269872; DOI=10.1016/j.neulet.2013.11.018; PMCID=PMC3903183;
RA   Bhattacherjee A., Liao Z.-H., Smith P.G.;
RT   "Trophic factor and hormonal regulation of neurite outgrowth in
RT   sensory neuron-like 50B11 cells.";
RL   Neurosci. Lett. 558:120-125(2014).
//
RX   PubMed=32636736; DOI=10.3389/fncel.2020.00184; PMCID=PMC7319018;
RA   Haberberger R.V., Barry C.M., Matusica D.;
RT   "Immortalized dorsal root ganglion neuron cell lines.";
RL   Front. Cell. Neurosci. 14:184.1-184.21(2020).
//
RX   PubMed=33307981; DOI=10.1177/1744806920970368; PMCID=PMC7745567;
RA   Matusica D., Canlas J., Martin M.A., Wei Y.-K., Marri S., Erickson A.,
RA   Barry C.M., Brierley S.M., Best O.G., Michael M.Z., Voelcker N.H.,
RA   Keating D.J., Haberberger R.V.;
RT   "Differentiation of the 50B11 dorsal root ganglion cells into NGF and
RT   GDNF responsive nociceptor subtypes.";
RL   Mol. Pain 16:1744806920970368.1-1744806920970368.20(2020).
//
RX   PubMed=35782611; DOI=10.1016/j.ymgmr.2022.100871; PMCID=PMC9248215;
RA   Kaneski C.R., Hanover J.A., Schueler Hoffman U.H.;
RT   "Generation of an in vitro model for peripheral neuropathy in Fabry
RT   disease using CRISPR-Cas9 in the nociceptive dorsal root ganglion
RT   cell line 50B11.";
RL   Mol. Genet. Metab. Rep. 31:100871.1-100871.8(2022).
//