Cellosaurus cell line SH-3 (CVCL

Cellosaurus SH-3 (CVCL_M383)

Cross-references
Cell line name	SH-3
Synonyms	SH3
Accession	CVCL_M383
Resource Identification Initiative	To cite this cell line use: SH-3 (RRID:CVCL_M383)
Comments	Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=1246601; PubMed=6451928; PubMed=20143388). Originally thought to originate from the pleural effusion of a 73 year old Caucasian female patient with a breast carcinoma. Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00087. Population: African American. Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18). Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease	Human papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_0030 (HeLa)
Sex of cell	Female
Age at sampling	30Y6M
Category	Cancer cell line
Web pages	Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications	CLPUB00114 Gabriel Seman, Sandra J. Hunter, Leon Dmochowski; Two cell lines (SH-2 and SH-3) derived from human breast cancer. Proc. Am. Assoc. Cancer Res. 16:59.234-59.234(1975) PubMed=1246601; DOI=10.1126/science.1246601 Walter Anthony Nelson-Rees, Robert R. Flandermeyer; HeLa cultures defined. Science 191:96-98(1976) PubMed=1260689; DOI=10.1002/1097-0142(197604)37:4<1814::AID-CNCR2820370428>3.0.CO;2-1 Gabriel Seman, Sandra J. Hunter, Richard C. Miller, Leon Dmochowski; Characterization of an established cell line (SH-3) derived from pleural effusion of patient with breast cancer. Cancer 37:1814-1824(1976) PubMed=72600 Brahma Sharma; In vitro immunization against human tumor cells with tumor cell fractions. Cancer Res. 37:4660-4668(1977) PubMed=6451928; DOI=10.1126/science.6451928 Walter Anthony Nelson-Rees, David W. Daniels, Robert R. Flandermeyer; Cross-contamination of cells in culture. Science 212:446-452(1981) CLPUB00262 Michael Gold; A conspiracy of cells. One woman's immortal legacy and the medical scandal it caused. (In book) ISBN 9780887060991; pp.1-171; State University of New York Press; Albany; USA (1986) PubMed=20143388; DOI=10.1002/ijc.25242 Amanda Capes-Davis, George Theodosopoulos, Isobel Atkin, Hans Gunther Drexler, Arihiro Kohara, Roderick A.F. MacLeod, John R.W. Masters, Yukio Nakamura, Yvonne A. Reid, Roger Robert Reddel, Robert Ian Freshney; Check your cultures! A list of cross-contaminated or misidentified cell lines. Int. J. Cancer 127:1-8(2010)
Biological sample resources	BioSample; SAMN03151758
Encyclopedic resources	Wikidata; Q54953201
Entry history
Entry creation	05-Nov-2013
Last entry update	10-Apr-2025
Version number	20