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Cellosaurus MDA-MB-468LN (CVCL_M372)

[Text version]
Cell line name MDA-MB-468LN
Synonyms MDA-MB-468GFP-LN; 468GFP-LN; 468LN
Accession CVCL_M372
Resource Identification Initiative To cite this cell line use: MDA-MB-468LN (RRID:CVCL_M372)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: African American.
Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
Omics: CNV analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; 9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; 9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_DH83 (MDA-MB-468GFP)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line

PubMed=16170671; DOI=10.1007/s10585-005-0745-1
Vantyghem S.A., Allan A.L., Postenka C.O., Al-Katib W., Keeney M., Tuck A.B., Chambers A.F.
A new model for lymphatic metastasis: development of a variant of the MDA-MB-468 human breast cancer cell line that aggressively metastasizes to lymph nodes.
Clin. Exp. Metastasis 22:351-361(2005)

PubMed=18262045; DOI=10.1016/j.cancergencyto.2007.05.030
Xu J., Chambers A.F., Tuck A.B., Rodenhiser D.I.
Molecular cytogenetic characterization of human breast cancer cell line MDA-MB-468 and its variant 468LN, which displays aggressive lymphatic metastasis.
Cancer Genet. Cytogenet. 181:1-7(2008)

PubMed=20084286; DOI=10.1371/journal.pone.0008665
Andrews J., Kennette W., Pilon J., Hodgson A., Tuck A.B., Chambers A.F., Rodenhiser D.I.
Multi-platform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number.
PLoS ONE 5:E8665-E8665(2010)

Encyclopedic resources Wikidata; Q54904647
Gene expression databases GEO; GSM390976
GEO; GSM390977
Polymorphism and mutation databases Progenetix; CVCL_M372
Entry history
Entry creation05-Nov-2013
Last entry update29-Jun-2023
Version number19