AC   CVCL_M372
SY   MDA-MB-468GFP-LN; 468GFP-LN; 468LN
DR   cancercelllines; CVCL_M372
DR   GEO; GSM390976
DR   GEO; GSM390977
DR   Progenetix; CVCL_M372
DR   Wikidata; Q54904647
RX   PubMed=16170671;
RX   PubMed=18262045;
RX   PubMed=20084286;
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Population: African American.
CC   Sequence variation: Mutation; HGNC; 9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Omics: CNV analysis.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C5214; Breast adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   51Y
CA   Cancer cell line
DT   Created: 05-11-13; Last updated: 05-10-23; Version: 20
RX   PubMed=16170671; DOI=10.1007/s10585-005-0745-1;
RA   Vantyghem S.A., Allan A.L., Postenka C.O., Al-Katib W., Keeney M.,
RA   Tuck A.B., Chambers A.F.;
RT   "A new model for lymphatic metastasis: development of a variant of the
RT   MDA-MB-468 human breast cancer cell line that aggressively
RT   metastasizes to lymph nodes.";
RL   Clin. Exp. Metastasis 22:351-361(2005).
RX   PubMed=18262045; DOI=10.1016/j.cancergencyto.2007.05.030;
RA   Xu J., Chambers A.F., Tuck A.B., Rodenhiser D.I.;
RT   "Molecular cytogenetic characterization of human breast cancer cell
RT   line MDA-MB-468 and its variant 468LN, which displays aggressive
RT   lymphatic metastasis.";
RL   Cancer Genet. Cytogenet. 181:1-7(2008).
RX   PubMed=20084286; DOI=10.1371/journal.pone.0008665;
RA   Andrews J., Kennette W., Pilon J., Hodgson A., Tuck A.B.,
RA   Chambers A.F., Rodenhiser D.I.;
RT   "Multi-platform whole-genome microarray analyses refine the epigenetic
RT   signature of breast cancer metastasis with gene expression and copy
RT   number.";
RL   PLoS ONE 5:E8665-E8665(2010).