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Cellosaurus MDA-MB-468GFP (CVCL_DH83)

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Cell line name MDA-MB-468GFP
Synonyms 468GFP
Accession CVCL_DH83
Resource Identification Initiative To cite this cell line use: MDA-MB-468GFP (RRID:CVCL_DH83)
Comments Group: Triple negative breast cancer (TNBC) cell line.
Population: African American.
Genetic integration: Method=Transfection/transduction; Gene=FPbase; R9NL8; eGFP (Note=Enhanced GFP).
Omics: Variations; CNV analysis.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Mutation; HGNC; HGNC:9588; PTEN; Simple; c.253+1G>T; ClinVar=VCV000189475; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:9884; RB1; Simple; c.265_2787del2523; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
Disease Breast adenocarcinoma (NCIt: C5214)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0419 (MDA-MB-468)
Children:
CVCL_M372 (MDA-MB-468LN)
Sex of cell Female
Age at sampling 51Y
Category Cancer cell line
Publications

PubMed=16170671; DOI=10.1007/s10585-005-0745-1
Sharon A. Vantyghem, Alison L. Allan, Carl O. Postenka, Waleed Al-Katib, Michael Keeney, Alan B. Tuck, Ann F. Chambers;
A new model for lymphatic metastasis: development of a variant of the MDA-MB-468 human breast cancer cell line that aggressively metastasizes to lymph nodes.
Clin. Exp. Metastasis 22:351-361(2005)

PubMed=20084286; DOI=10.1371/journal.pone.0008665; PMCID=PMC2801616
Joseph D. Andrews, Wendy Kennette, Jenna Pilon, Alexandra Hodgson, Alan B. Tuck, Ann F. Chambers, David I. Rodenhiser;
Multi-platform whole-genome microarray analyses refine the epigenetic signature of breast cancer metastasis with gene expression and copy number.
PLoS ONE 5:e8665.1-e8665.17(2010)

Cross-references
Cell line databases/resources cancercelllines; CVCL_DH83
Encyclopedic resources Wikidata; Q54904646
Gene expression databases GEO; GSM390975
GEO; GSM390978
Polymorphism and mutation databases Progenetix; CVCL_DH83
Entry history
Entry creation13-Jul-2016
Last entry update10-Apr-2025
Version number18