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Cellosaurus NKI-SC263 (CVCL_LI51)

[Text version]
Cell line name NKI-SC263
Synonyms SC263; Nederlands Kanker Instituut-Squamous cell Carcinoma 263
Accession CVCL_LI51
Resource Identification Initiative To cite this cell line use: NKI-SC263 (RRID:CVCL_LI51)
Comments Doubling time: 35-40 hours (Direct_author_submission).
Miscellaneous: Doubling time and CDKN2A status from personal communication of Dok, Ruveyda.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous; Note=Possible (Direct_author_submission).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; c.704_735del32; Zygosity=Unspecified (PubMed=25184754).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=25184754).
Disease Head and neck squamous cell carcinoma (NCIt: C34447)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LI56 (SC263 R10.2)
Category Cancer cell line
Publications

PubMed=12175565; DOI=10.1016/S0167-8140(01)00498-4
Adrian C. Begg, Debbie Sprong, Alfons J.M. Balm, Jose M. Coco-Martin;
Premature chromosome condensation and cell separation studies in biopsies from head and neck tumors for radiosensitivity prediction.
Radiother. Oncol. 62:335-343(2002)

PubMed=25184754; DOI=10.1371/journal.pone.0106301; PMCID=PMC4153646
Selda Aydin, Anne-France Dekairelle, Jerome Ambroise, Jean-Francois Durant, Michel Heusterspreute, Yves Guiot, Jean-Pierre Cosyns, Jean-Luc Gala;
Unambiguous detection of multiple TP53 gene mutations in AAN-associated urothelial cancer in Belgium using laser capture microdissection.
PLoS ONE 9:e106301.1-e106301.9(2014)

PubMed=26032726; DOI=10.1186/s13104-015-1197-6; PMCID=PMC4467624
Carolien Boeckx, Jolien Van den Bossche, Ines De Pauw, Marc Peeters, Filip Lardon, Marc Baay, An Wouters;
The hypoxic tumor microenvironment and drug resistance against EGFR inhibitors: preclinical study in cetuximab-sensitive head and neck squamous cell carcinoma cell lines.
BMC Res. Notes 8:203.1-203.6(2015)

PubMed=26269754; PMCID=PMC4529614
Carolien Boeckx, Lina Blockx, Ken Op de Beeck, Ridha Limame, Guy Van Camp, Marc Peeters, Jan B. Vermorken, Pol Specenier, An Wouters, Marc Baay, Filip Lardon;
Establishment and characterization of cetuximab resistant head and neck squamous cell carcinoma cell lines: focus on the contribution of the AP-1 transcription factor.
Am. J. Cancer Res. 5:1921-1938(2015)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LI51
Encyclopedic resources Wikidata; Q54930678
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number13