ID   NKI-SC263
AC   CVCL_LI51
SY   SC263; Nederlands Kanker Instituut-Squamous cell Carcinoma 263
DR   cancercelllines; CVCL_LI51
DR   Wikidata; Q54930678
RX   PubMed=12175565;
RX   PubMed=25184754;
RX   PubMed=26032726;
RX   PubMed=26269754;
CC   Doubling time: 35-40 hours (Direct_author_submission).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous; Note=Possible (Direct_author_submission).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.704_735del32; Zygosity=Unspecified (PubMed=25184754).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg306Ter (c.916C>T); ClinVar=VCV000142144; Zygosity=Unspecified (PubMed=25184754).
CC   Miscellaneous: Doubling time and CDKN2A status from personal communication of Dok, Ruveyda.
DI   NCIt; C34447; Head and neck squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 15-11-17; Last updated: 19-12-24; Version: 13
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RX   PubMed=12175565; DOI=10.1016/S0167-8140(01)00498-4;
RA   Begg A.C., Sprong D., Balm A.J.M., Coco-Martin J.M.;
RT   "Premature chromosome condensation and cell separation studies in
RT   biopsies from head and neck tumors for radiosensitivity prediction.";
RL   Radiother. Oncol. 62:335-343(2002).
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RX   PubMed=25184754; DOI=10.1371/journal.pone.0106301; PMCID=PMC4153646;
RA   Aydin S., Dekairelle A.-F., Ambroise J., Durant J.-F.,
RA   Heusterspreute M., Guiot Y., Cosyns J.-P., Gala J.-L.;
RT   "Unambiguous detection of multiple TP53 gene mutations in
RT   AAN-associated urothelial cancer in Belgium using laser capture
RT   microdissection.";
RL   PLoS ONE 9:e106301.1-e106301.9(2014).
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RX   PubMed=26032726; DOI=10.1186/s13104-015-1197-6; PMCID=PMC4467624;
RA   Boeckx C., Van den Bossche J., De Pauw I., Peeters M., Lardon F.,
RA   Baay M., Wouters A.;
RT   "The hypoxic tumor microenvironment and drug resistance against EGFR
RT   inhibitors: preclinical study in cetuximab-sensitive head and neck
RT   squamous cell carcinoma cell lines.";
RL   BMC Res. Notes 8:203.1-203.6(2015).
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RX   PubMed=26269754; PMCID=PMC4529614;
RA   Boeckx C., Blockx L., Op de Beeck K., Limame R., Van Camp G.,
RA   Peeters M., Vermorken J.B., Specenier P., Wouters A., Baay M.,
RA   Lardon F.;
RT   "Establishment and characterization of cetuximab resistant head and
RT   neck squamous cell carcinoma cell lines: focus on the contribution of
RT   the AP-1 transcription factor.";
RL   Am. J. Cancer Res. 5:1921-1938(2015).
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