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Cellosaurus HuH-7T1 (CVCL_LG22)

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Cell line name HuH-7T1
Accession CVCL_LG22
Resource Identification Initiative To cite this cell line use: HuH-7T1 (RRID:CVCL_LG22)
Comments Population: Japanese.
Virology: Compared to the parent Huh-7 cell line, permits improved hepatitis C virus (HCV) production when infected with strain JFH-1.
Derived from site: In situ; Liver; UBERON=UBERON_0002107.
Sequence variations
  • Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
Disease Adult hepatocellular carcinoma (NCIt: C7956)
Adult hepatocellular carcinoma (ORDO: Orphanet_210159)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0336 (Huh-7)
Sex of cell Male
Age at sampling 57Y
Category Cancer cell line
Publications

PubMed=23285155; DOI=10.1371/journal.pone.0052697; PMCID=PMC3527576
Asako Murayama, Nao Sugiyama, Seiko Yoshimura, Mitsuko Ishihara-Sugano, Takahiro Masaki, Sulyi Kim, Takaji Wakita, Shunji Mishiro, Takanobu Kato;
A subclone of HuH-7 with enhanced intracellular hepatitis C virus production and evasion of virus related-cell cycle arrest.
PLoS ONE 7:e52697.1-e52697.9(2012)

Cross-references
Cell line databases/resources cancercelllines; CVCL_LG22
Encyclopedic resources Wikidata; Q54896859
Entry history
Entry creation15-Nov-2017
Last entry update19-Dec-2024
Version number15