ID   HuH-7T1
AC   CVCL_LG22
DR   cancercelllines; CVCL_LG22
DR   Wikidata; Q54896859
RX   PubMed=23285155;
CC   Population: Japanese.
CC   Virology: Compared to the parent Huh-7 cell line, permits improved hepatitis C virus (HCV) production when infected with strain JFH-1.
CC   Sequence variation: Mutation; HGNC; HGNC:6307; KDR; Simple; p.Gln472His (c.1416A>T); ClinVar=VCV000134603; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:20932; POLD3; Simple; p.Lys109Arg (c.326A>G) (p.Lys70Arg, c.209A>G); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Tyr220Cys (c.659A>G); ClinVar=VCV000127819; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0336 ! Huh-7
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 15-11-17; Last updated: 19-12-24; Version: 15
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RX   PubMed=23285155; DOI=10.1371/journal.pone.0052697; PMCID=PMC3527576;
RA   Murayama, Asako
RA   Sugiyama, Nao
RA   Yoshimura, Seiko
RA   Ishihara-Sugano, Mitsuko
RA   Masaki, Takahiro
RA   Kim, Sulyi
RA   Wakita, Takaji
RA   Mishiro, Shunji
RA   Kato, Takanobu
RT   "A subclone of HuH-7 with enhanced intracellular hepatitis C virus
RT   production and evasion of virus related-cell cycle arrest.";
RL   PLoS ONE 7:e52697.1-e52697.9(2012).
//