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Cellosaurus NIH 3T3/HER2-3(400) (CVCL_LG16)

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Cell line name NIH 3T3/HER2-3(400)
Synonyms NIH 3T3/HER2-3 400; NIH 3T3/HER2-3400
Accession CVCL_LG16
Resource Identification Initiative To cite this cell line use: NIH 3T3/HER2-3(400) (RRID:CVCL_LG16)
Comments Characteristics: Transfected with at least 55 copies of ERBB2 under the control of a SV40 promoter (PubMed=2890160).
Genetic integration: Method=Transfection; Gene=HGNC; HGNC:3430; ERBB2.
Genetic integration: Method=Transfection; Gene=MGI; MGI:94890; Dhfr.
Genetic integration: Method=Transfection; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Derived from site: In situ; Whole embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: NIH Swiss.
Hierarchy Parent: CVCL_0594 (NIH 3T3)
Sex of cell Male
Age at sampling Embryo
Category Spontaneously immortalized cell line
Publications

PubMed=2890160; DOI=10.1073/pnas.84.20.7159; PMCID=PMC299249
Robert M. Hudziak, Joseph Schlessinger, Axel Ullrich;
Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.
Proc. Natl. Acad. Sci. U.S.A. 84:7159-7163(1987)

PubMed=2566907; DOI=10.1128/mcb.9.3.1165-1172.1989; PMCID=PMC362707
Robert M. Hudziak, Gail D. Lewis Phillips, Marcy Winget, Brian M. Fendly, H. Michael Shepard, Axel Ullrich;
p185HER2 monoclonal antibody has antiproliferative effects in vitro and sensitizes human breast tumor cells to tumor necrosis factor.
Mol. Cell. Biol. 9:1165-1172(1989)

PubMed=1689212
Brian M. Fendly, Marcy Winget, Robert M. Hudziak, Michael T. Lipari, Mary Anna Napier, Axel Ullrich;
Characterization of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product.
Cancer Res. 50:1550-1558(1990)

Cross-references
Encyclopedic resources Wikidata; Q54930583
Entry history
Entry creation15-Nov-2017
Last entry update14-Aug-2025
Version number9