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Cellosaurus NES2Y (CVCL_LB86)

[Text version]
Cell line name NES2Y
Synonyms NES 2Y
Accession CVCL_LB86
Resource Identification Initiative To cite this cell line use: NES2Y (RRID:CVCL_LB86)
Comments Group: Patented cell line.
Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 98081006.
Characteristics: Insulin secreting.
Characteristics: Has a loss of function of ATP-regulated potassium channels.
Disease Persistent hyperinsulinemic hypoglycemia of infancy (NCIt: C122923)
Autosomal dominant hyperinsulinism due to SUR1 deficiency (ORDO: Orphanet_276575)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LB87 (NISK9)
Category Spontaneously immortalized cell line
Publications

PubMed=9280302; DOI=10.1016/S0014-5793(97)00874-0
Macfarlane W.M., Cragg H., Docherty H.M., Read M.L., James R.F.L., Aynsley-Green A., Docherty K.
Impaired expression of transcription factor IUF1 in a pancreatic beta-cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis).
FEBS Lett. 413:304-308(1997)

PubMed=10567373; DOI=10.1074/jbc.274.48.34059
Macfarlane W.M., Chapman J.C., Shepherd R.M., Hashmi M.N., Kamimura N., Cosgrove K.E., O'Brien R.E., Barnes P.D., Hart A.W., Docherty H.M., Lindley K.J., Aynsley-Green A., James R.F.L., Docherty K., Dunne M.J.
Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.
J. Biol. Chem. 274:34059-34066(1999)

PubMed=10866047; DOI=10.2337/diabetes.49.6.953
Macfarlane W.M., O'Brien R.E., Barnes P.D., Shepherd R.M., Cosgrove K.E., Lindley K.J., Aynsley-Green A., James R.F.L., Docherty K., Dunne M.J.
Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y.
Diabetes 49:953-960(2000)

Patent=US6372501
Aynsley-Green A., Lindley K.J., Docherty K., Dunne M.J., Macfarlane W.M., James R.F.L.
Glucose responsive beta-cell line.
Patent number US6372501, 16-Apr-2002

PubMed=21099259; DOI=10.4161/isl.1.2.9432
Adams G.G., Uddin A., Vives-Pi M., Pujol-Borrell R., James R.F.L.
Characterisation of the NES2Y cell line and its use in the production of human glucose-responsive insulin producing (hGRIP) cell lines by cell-cell fusion.
Islets 1:117-123(2009)

Cross-references
Encyclopedic resources Wikidata; Q54930415
Entry history
Entry creation22-Aug-2017
Last entry update21-Mar-2023
Version number6