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Cellosaurus NES2Y (CVCL_LB86)

[Text version]
Cell line name NES2Y
Synonyms NES 2Y
Accession CVCL_LB86
Resource Identification Initiative To cite this cell line use: NES2Y (RRID:CVCL_LB86)
Comments Group: Patented cell line.
Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 98081006.
Characteristics: Insulin secreting.
Characteristics: Has a loss of function of ATP-regulated potassium channels.
Disease Persistent hyperinsulinemic hypoglycemia of infancy (NCIt: C122923)
Autosomal dominant hyperinsulinism due to SUR1 deficiency (ORDO: Orphanet_276575)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_LB87 (NISK9)
Category Spontaneously immortalized cell line
Publications

PubMed=9280302; DOI=10.1016/S0014-5793(97)00874-0
Wendy M. Macfarlane, Helen Cragg, Hilary M. Docherty, Martin L. Read, Roger Frank Lever James, Albert Aynsley-Green, Kevin Docherty;
Impaired expression of transcription factor IUF1 in a pancreatic beta-cell line derived from a patient with persistent hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis).
FEBS Lett. 413:304-308(1997)

PubMed=10567373; DOI=10.1074/jbc.274.48.34059
Wendy M. Macfarlane, Joanna C. Chapman, Ruth M. Shepherd, Molly N. Hashmi, Noritaka Kamimura, Karen E. Cosgrove, Rachel E. O'Brien, Philippa D. Barnes, Alan W. Hart, Hilary M. Docherty, Keith J. Lindley ...Show all 15 authors... , Albert Aynsley-Green, Roger Frank Lever James, Kevin Docherty, Mark J. Dunne; Show fewer authors
Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.
J. Biol. Chem. 274:34059-34066(1999)

PubMed=10866047; DOI=10.2337/diabetes.49.6.953
Wendy M. Macfarlane, Rachel E. O'Brien, Philippa D. Barnes, Ruth M. Shepherd, Karen E. Cosgrove, Keith J. Lindley, Albert Aynsley-Green, Roger Frank Lever James, Kevin Docherty, Mark J. Dunne;
Sulfonylurea receptor 1 and Kir6.2 expression in the novel human insulin-secreting cell line NES2Y.
Diabetes 49:953-960(2000)

Patent=US6372501
Albert Aynsley-Green, Keith J. Lindley, Kevin Docherty, Mark J. Dunne, Wendy M. Macfarlane, Roger Frank Lever James;
Glucose responsive beta-cell line.
Patent number US6372501, 16-Apr-2002

PubMed=21099259; DOI=10.4161/isl.1.2.9432
Gary G. Adams, Akklaque Uddin, Marta Vives-Pi, Ricardo Pujol-Borrell, Roger Frank Lever James;
Characterisation of the NES2Y cell line and its use in the production of human glucose-responsive insulin producing (hGRIP) cell lines by cell-cell fusion.
Islets 1:117-123(2009)

Cross-references
Encyclopedic resources Wikidata; Q54930415
Entry history
Entry creation22-Aug-2017
Last entry update21-Mar-2023
Version number6