ID   NES2Y
AC   CVCL_LB86
SY   NES 2Y
DR   Wikidata; Q54930415
RX   Patent=US6372501;
RX   PubMed=9280302;
RX   PubMed=10567373;
RX   PubMed=10866047;
RX   PubMed=21099259;
CC   Group: Patented cell line.
CC   Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 98081006.
CC   Characteristics: Insulin secreting.
CC   Characteristics: Has a loss of function of ATP-regulated potassium channels.
DI   NCIt; C122923; Persistent hyperinsulinemic hypoglycemia of infancy
DI   ORDO; Orphanet_276575; Autosomal dominant hyperinsulinism due to SUR1 deficiency
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Spontaneously immortalized cell line
DT   Created: 22-08-17; Last updated: 21-03-23; Version: 6
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RX   Patent=US6372501;
RA   Aynsley-Green A., Lindley K.J., Docherty K., Dunne M.J.,
RA   Macfarlane W.M., James R.F.L.;
RT   "Glucose responsive beta-cell line.";
RL   Patent number US6372501, 16-Apr-2002.
//
RX   PubMed=9280302; DOI=10.1016/S0014-5793(97)00874-0;
RA   Macfarlane W.M., Cragg H., Docherty H.M., Read M.L., James R.F.L.,
RA   Aynsley-Green A., Docherty K.;
RT   "Impaired expression of transcription factor IUF1 in a pancreatic
RT   beta-cell line derived from a patient with persistent
RT   hyperinsulinaemic hypoglycaemia of infancy (nesidioblastosis).";
RL   FEBS Lett. 413:304-308(1997).
//
RX   PubMed=10567373; DOI=10.1074/jbc.274.48.34059;
RA   Macfarlane W.M., Chapman J.C., Shepherd R.M., Hashmi M.N.,
RA   Kamimura N., Cosgrove K.E., O'Brien R.E., Barnes P.D., Hart A.W.,
RA   Docherty H.M., Lindley K.J., Aynsley-Green A., James R.F.L.,
RA   Docherty K., Dunne M.J.;
RT   "Engineering a glucose-responsive human insulin-secreting cell line
RT   from islets of Langerhans isolated from a patient with persistent
RT   hyperinsulinemic hypoglycemia of infancy.";
RL   J. Biol. Chem. 274:34059-34066(1999).
//
RX   PubMed=10866047; DOI=10.2337/diabetes.49.6.953;
RA   Macfarlane W.M., O'Brien R.E., Barnes P.D., Shepherd R.M.,
RA   Cosgrove K.E., Lindley K.J., Aynsley-Green A., James R.F.L.,
RA   Docherty K., Dunne M.J.;
RT   "Sulfonylurea receptor 1 and Kir6.2 expression in the novel human
RT   insulin-secreting cell line NES2Y.";
RL   Diabetes 49:953-960(2000).
//
RX   PubMed=21099259; DOI=10.4161/isl.1.2.9432;
RA   Adams G.G., Uddin A., Vives-Pi M., Pujol-Borrell R., James R.F.L.;
RT   "Characterisation of the NES2Y cell line and its use in the production
RT   of human glucose-responsive insulin producing (hGRIP) cell lines by
RT   cell-cell fusion.";
RL   Islets 1:117-123(2009).
//