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Cellosaurus NISK9 (CVCL_LB87)

[Text version]
Cell line name NISK9
Synonyms NISK 9
Accession CVCL_LB87
Resource Identification Initiative To cite this cell line use: NISK9 (RRID:CVCL_LB87)
Comments Group: Patented cell line.
Registration: International Depositary Authority, European Collection of Cell Cultures (ECACC); 09709106.
Characteristics: Insulin secreting.
Characteristics: Compared to the parent cell line, it has a repaired ATP-regulated potassium channel activity.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:59; ABCC8.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6257; KCNJ11.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:6107; PDX1.
Disease Persistent hyperinsulinemic hypoglycemia of infancy (NCIt: C122923)
Autosomal dominant hyperinsulinism due to SUR1 deficiency (ORDO: Orphanet_276575)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_LB86 (NES2Y)
Category Spontaneously immortalized cell line
Publications

PubMed=10567373; DOI=10.1074/jbc.274.48.34059
Wendy M. Macfarlane, Joanna C. Chapman, Ruth M. Shepherd, Molly N. Hashmi, Noritaka Kamimura, Karen E. Cosgrove, Rachel E. O'Brien, Philippa D. Barnes, Alan W. Hart, Hilary M. Docherty, Keith J. Lindley ...Show all 15 authors... , Albert Aynsley-Green, Roger Frank Lever James, Kevin Docherty, Mark J. Dunne; Show fewer authors
Engineering a glucose-responsive human insulin-secreting cell line from islets of Langerhans isolated from a patient with persistent hyperinsulinemic hypoglycemia of infancy.
J. Biol. Chem. 274:34059-34066(1999)

Patent=US6372501
Albert Aynsley-Green, Keith J. Lindley, Kevin Docherty, Mark J. Dunne, Wendy M. Macfarlane, Roger Frank Lever James;
Glucose responsive beta-cell line.
Patent number US6372501, 16-Apr-2002

Cross-references
Encyclopedic resources Wikidata; Q54930632
Entry history
Entry creation22-Aug-2017
Last entry update19-Dec-2024
Version number8