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Cellosaurus POE9n (CVCL_L237)

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Cell line name POE9n
Accession CVCL_L237
Resource Identification Initiative To cite this cell line use: POE9n (RRID:CVCL_L237)
Comments Senescence: Senesces at ~85 PDL (PubMed=10648628).
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Cell type: Keratinocyte; CL=CL_0000312.
Sequence variations
Disease Oral epithelial dysplasia (NCIt: C129863)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_L238 (POE9n/TERT)
Sex of cell Male
Age at sampling 65Y
Category Finite cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Mark A. Dickson, William Chun Hahn, Yasushi Ino, Vincent Ronfard, Jenny Y. Wu, Robert Allan Weinberg, David Neil Louis, Frederick Pei Li, James George Rheinwald;
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780
James George Rheinwald, William Chun Hahn, Matthew Robert Ramsey, Jenny Y. Wu, Zong-You Guo, Hensin Tsao, Michele De Luca, Caterina Catricala, Kathleen M. O'Toole;
A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status.
Mol. Cell. Biol. 22:5157-5172(2002)

PubMed=22546478; DOI=10.1016/j.ajpath.2012.02.028; PMCID=PMC3378915
Martin Degen, Easwar Natarajan, Patricia Barron, Hans R. Widlund, James George Rheinwald;
MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin gamma2 expression in oral dysplasia and squamous cell carcinoma.
Am. J. Pathol. 180:2462-2478(2012)

Cross-references
Encyclopedic resources Wikidata; Q54947698
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number15