ID   POE9n
AC   CVCL_L237
DR   Wikidata; Q54947698
RX   PubMed=10648628;
RX   PubMed=12077343;
RX   PubMed=22546478;
WW   Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
CC   Senescence: Senesces at ~85 PDL (PubMed=10648628).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=12077343).
CC   Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
CC   Cell type: Keratinocyte; CL=CL_0000312.
DI   NCIt; C129863; Oral epithelial dysplasia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   65Y
CA   Finite cell line
DT   Created: 06-05-13; Last updated: 10-04-25; Version: 15
//
RX   PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304;
RA   Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A.,
RA   Louis D.N., Li F.P., Rheinwald J.G.;
RT   "Human keratinocytes that express hTERT and also bypass a
RT   p16(INK4a)-enforced mechanism that limits life span become immortal yet
RT   retain normal growth and differentiation characteristics.";
RL   Mol. Cell. Biol. 20:1436-1447(2000).
//
RX   PubMed=12077343; DOI=10.1128/mcb.22.14.5157-5172.2002; PMCID=PMC139780;
RA   Rheinwald J.G., Hahn W.C., Ramsey M.R., Wu J.Y., Guo Z.-Y., Tsao H.,
RA   De Luca M., Catricala C., O'Toole K.M.;
RT   "A two-stage, p16(INK4A)- and p53-dependent keratinocyte senescence
RT   mechanism that limits replicative potential independent of telomere
RT   status.";
RL   Mol. Cell. Biol. 22:5157-5172(2002).
//
RX   PubMed=22546478; DOI=10.1016/j.ajpath.2012.02.028; PMCID=PMC3378915;
RA   Degen M., Natarajan E., Barron P., Widlund H.R., Rheinwald J.G.;
RT   "MAPK/ERK-dependent translation factor hyperactivation and
RT   dysregulated laminin gamma2 expression in oral dysplasia and squamous
RT   cell carcinoma.";
RL   Am. J. Pathol. 180:2462-2478(2012).
//