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Cellosaurus OKF6/TERT-2 (CVCL_L225)

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Cell line name OKF6/TERT-2
Synonyms OKF6 Tert 2; OKF6 TERT2
Accession CVCL_L225
Resource Identification Initiative To cite this cell line use: OKF6/TERT-2 (RRID:CVCL_L225)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_L222 (OKF6)
Sex of cell Male
Age at sampling 57Y
Category Telomerase immortalized cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81812,13
D7S8208,10
D13S31711
D16S53911,12
TH016,9.3
TPOX9,11
vWA14,15

Run an STR similarity search on this cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Mark A. Dickson, William Chun Hahn, Yasushi Ino, Vincent Ronfard, Jenny Y. Wu, Robert Allan Weinberg, David Neil Louis, Frederick Pei Li, James George Rheinwald;
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Mei Zhao, Daisuke Sano, Curtis R. Pickering, Samar A. Jasser, Ying C. Henderson, Gary L. Clayman, Erich M. Sturgis, Thomas J. Ow, Reuben Lotan, Thomas E. Carey, Peter G. Sacks ...Show all 15 authors... , Jennifer Rubin Grandis, David Sidransky, Nils-Erik Heldin, Jeffrey N. Myers; Show fewer authors
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=25169794; DOI=10.1111/jop.12236
Christopher T.D. Dickman, Rebecca Towle, Rajan Saini, Cathie Garnis;
Molecular characterization of immortalized normal and dysplastic oral cell lines.
J. Oral Pathol. Med. 44:329-336(2015)

Cross-references
Encyclopedic resources Wikidata; Q54931923
Gene expression databases GEO; GSM1431130
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number15