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Cellosaurus OKF6/TERT-2 (CVCL_L225)

[Text version]
Cell line name OKF6/TERT-2
Synonyms OKF6 Tert 2; OKF6 TERT2
Accession CVCL_L225
Resource Identification Initiative To cite this cell line use: OKF6/TERT-2 (RRID:CVCL_L225)
Comments Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
Omics: Transcriptomics; Microarray.
Omics: Variations; Array-based CGH.
Omics: Variations; CNV analysis.
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_L222 (OKF6)
Sex of cell Male
Age at sampling 57Y
Category Telomerase immortalized cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX,Y
CSF1PO11,12
D5S81812,13
D7S8208,10
D13S31711
D16S53911,12
TH016,9.3
TPOX9,11
vWA14,15

Run an STR similarity search on this cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Dickson M.A., Hahn W.C., Ino Y., Ronfard V., Wu J.Y., Weinberg R.A., Louis D.N., Li F.P., Rheinwald J.G.
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690; PMCID=PMC3229662
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

PubMed=25169794; DOI=10.1111/jop.12236
Dickman C.T.D., Towle R., Saini R., Garnis C.
Molecular characterization of immortalized normal and dysplastic oral cell lines.
J. Oral Pathol. Med. 44:329-336(2015)

Cross-references
Encyclopedic resources Wikidata; Q54931923
Gene expression databases GEO; GSM1431130
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number15