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Cellosaurus OKF6 (CVCL_L222)

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Cell line name OKF6
Synonyms OK-F6; OKF-6; OKF/6
Accession CVCL_L222
Resource Identification Initiative To cite this cell line use: OKF6 (RRID:CVCL_L222)
Comments Senescence: Senesces at ~45 PDL (PubMed=10648628).
Derived from site: In situ; Oral cavity, floor of mouth; UBERON=UBERON_0003679.
Cell type: Keratinocyte; CL=CL_0000312.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_L223 (OKF6/E6E7)CVCL_L224 (OKF6/TERT-1)CVCL_L225 (OKF6/TERT-2)
Sex of cell Male
Age at sampling 57Y
Category Finite cell line
Web pages Provider; BWH dermatology; -; https://dermatology.bwh.harvard.edu/docs/Cell-Culture-Core-Cell-Lines.pdf
Publications

PubMed=10648628; DOI=10.1128/mcb.20.4.1436-1447.2000; PMCID=PMC85304
Mark A. Dickson, William Chun Hahn, Yasushi Ino, Vincent Ronfard, Jenny Y. Wu, Robert Allan Weinberg, David Neil Louis, Frederick Pei Li, James George Rheinwald;
Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics.
Mol. Cell. Biol. 20:1436-1447(2000)

PubMed=22546478; DOI=10.1016/j.ajpath.2012.02.028; PMCID=PMC3378915
Martin Degen, Easwar Natarajan, Patricia Barron, Hans R. Widlund, James George Rheinwald;
MAPK/ERK-dependent translation factor hyperactivation and dysregulated laminin gamma2 expression in oral dysplasia and squamous cell carcinoma.
Am. J. Pathol. 180:2462-2478(2012)

Cross-references
Anatomy/cell type resources BTO; BTO_0005374
Encyclopedic resources Wikidata; Q54931920
Entry history
Entry creation06-May-2013
Last entry update10-Apr-2025
Version number13