Cellosaurus logo
expasy logo

Cellosaurus HGrC1 (CVCL_KB28)

[Text version]
Cell line name HGrC1
Synonyms hGrC1
Accession CVCL_KB28
Resource Identification Initiative To cite this cell line use: HGrC1 (RRID:CVCL_KB28)
Comments Characteristics: Has FSH-responsive aromatase activity, inducible FSHR expression and responsiveness to the TGF-beta superfamily (PubMed=22467494).
Doubling time: ~40 hours (PubMed=22467494).
Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16) [pLXSN16E6E7].
Derived from sampling site: Ovary; ovarian follicle; granulosa cell layer.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
Sex of cell Female
Age at sampling 35Y
Category Transformed cell line

PubMed=22467494; DOI=10.1210/en.2011-1810
Bayasula X., Iwase A., Kiyono T., Takikawa S., Goto M., Nakamura T., Nagatomo Y., Nakahara T., Kotani T., Kobayashi H., Kondo M., Manabe S., Kikkawa F.
Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status.
Endocrinology 153:2851-2860(2012)

PubMed=31079267; DOI=10.1007/s10815-019-01469-y
Shimizu K., Nakamura T., Bayasula X., Nakanishi N., Kasahara Y., Nagai T., Murase T., Osuka S., Goto M., Iwase A., Kikkawa F.
Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells.
J. Assist. Reprod. Genet. 36:1185-1194(2019)

PubMed=34888112; DOI=10.1016/j.scib.2020.03.040
Lv X.-M., He C.-B., Huang C., Hua G.-H., Chen X.-C., Timm B.K., Maclin V.M., Haggerty A.A., Aust S.K., Golden D.M., Dave B.J., Tseng Y.-A., Chen L., Wang H.-B., Chen P.-C., Klinkebiel D.L., Karpf A.R., Dong J.-X., Drapkin R.I., Rueda B.R., Davis J.S., Wang C.
Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features.
Sci. Bull. 65:1281-1296(2020)

Encyclopedic resources Wikidata; Q54887322
Entry history
Entry creation22-Aug-2017
Last entry update21-Mar-2023
Version number8