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Cellosaurus HGrC1 (CVCL_KB28)

[Text version]
Cell line name HGrC1
Synonyms hGrC1
Accession CVCL_KB28
Resource Identification Initiative To cite this cell line use: HGrC1 (RRID:CVCL_KB28)
Comments Characteristics: Has FSH-responsive aromatase activity, inducible FSHR expression and responsiveness to the TGF-beta superfamily (PubMed=22467494).
Doubling time: ~40 hours (PubMed=22467494).
Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6.
Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7.
Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
Cell type: Granulosa cell; CL=CL_0000501.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_E3DE (HGrC1-MXIV)CVCL_E3DD (HGrC1-TP53(R175H))CVCL_A0TX (HGrC1-YAP)
CVCL_A0TY (HGrC1-YAP(S127A))
Sex of cell Female
Age at sampling 35Y
Category Transformed cell line
Publications

PubMed=22467494; DOI=10.1210/en.2011-1810
Bayasula No_last_name, Akira Iwase, Tohru Kiyono, Sachiko Takikawa, Maki Goto, Tomoko Nakamura, Yoshinari Nagatomo, Tatsuo Nakahara, Tomomi Kotani, Hiroharu Kobayashi, Mika Kondo ...Show all 13 authors... , Shuichi Manabe, Fumitaka Kikkawa; Show fewer authors
Establishment of a human nonluteinized granulosa cell line that transitions from the gonadotropin-independent to the gonadotropin-dependent status.
Endocrinology 153:2851-2860(2012)

PubMed=31079267; DOI=10.1007/s10815-019-01469-y; PMCID=PMC6603124
Ken Shimizu, Tomoko Nakamura, Bayasula No_last_name, Natsuki Nakanishi, Yukiyo Kasahara, Takashi Nagai, Tomohiko Murase, Satoko Osuka, Maki Goto, Akira Iwase, Fumitaka Kikkawa;
Molecular mechanism of FSHR expression induced by BMP15 in human granulosa cells.
J. Assist. Reprod. Genet. 36:1185-1194(2019)

PubMed=34888112; DOI=10.1016/j.scib.2020.03.040; PMCID=PMC8654108
Xiang-Min Lv, Chun-Bo He, Cong Huang, Guo-Hua Hua, Xing-Cheng Chen, Barbara K. Timm, Victoria M. Maclin, Abigail A. Haggerty, Shelly K. Aust, Denae M. Golden, Bhavana J. Dave ...Show all 22 authors... , Yun-An Tseng, Li Chen, Hong-Bo Wang, Pei-Chao Chen, David L. Klinkebiel, Adam R. Karpf, Ji-Xin Dong, Ronny I. Drapkin, Bo R. Rueda, John S. Davis, Cheng Wang; Show fewer authors
Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features.
Sci. Bull. 65:1281-1296(2020)

Cross-references
Encyclopedic resources Wikidata; Q54887322
Entry history
Entry creation22-Aug-2017
Last entry update14-Aug-2025
Version number13