Cellosaurus cell line HGrC1-YAP(S127A) (CVCL

Cellosaurus HGrC1-YAP(S127A) (CVCL_A0TY)

Cross-references
Cell line name	HGrC1-YAP(S127A)
Synonyms	HGrC1-YAPS127A
Accession	CVCL_A0TY
Resource Identification Initiative	To cite this cell line use: HGrC1-YAP(S127A) (RRID:CVCL_A0TY)
Comments	Genetic integration: Method=Transduction; Gene=HGNC; HGNC:16262; YAP1 (Note=With p.Ser127Ala). Genetic integration: Method=Transduction; Gene=UniProtKB; P03126; Human papillomavirus type 16 protein E6. Genetic integration: Method=Transduction; Gene=UniProtKB; P03129; Human papillomavirus type 16 protein E7. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo. Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16). Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170. Cell type: Granulosa cell; CL=CL_0000501.
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy	Parent: CVCL_KB28 (HGrC1)
Sex of cell	Female
Age at sampling	35Y
Category	Transformed cell line
Publications	PubMed=34888112; DOI=10.1016/j.scib.2020.03.040; PMCID=PMC8654108 Xiang-Min Lv, Chun-Bo He, Cong Huang, Guo-Hua Hua, Xing-Cheng Chen, Barbara K. Timm, Victoria M. Maclin, Abigail A. Haggerty, Shelly K. Aust, Denae M. Golden, Bhavana J. Dave ...Show all 22 authors... , Yun-An Tseng, Li Chen, Hong-Bo Wang, Pei-Chao Chen, David L. Klinkebiel, Adam R. Karpf, Ji-Xin Dong, Ronny I. Drapkin, Bo R. Rueda, John S. Davis, Cheng Wang; Show fewer authors Reprogramming of ovarian granulosa cells by YAP1 leads to development of high-grade cancer with mesenchymal lineage and serous features. Sci. Bull. 65:1281-1296(2020)
Encyclopedic resources	Wikidata; Q108820466
Entry history
Entry creation	23-Sep-2021
Last entry update	14-Aug-2025
Version number	9