ID   HGrC1
AC   CVCL_KB28
SY   hGrC1
DR   Wikidata; Q54887322
RX   PubMed=22467494;
RX   PubMed=31079267;
RX   PubMed=34888112;
CC   Characteristics: Has FSH-responsive aromatase activity, inducible FSHR expression and responsiveness to the TGF-beta superfamily (PubMed=22467494).
CC   Doubling time: ~40 hours (PubMed=22467494).
CC   Transfected with: UniProtKB; P03126; Human papillomavirus type 16 protein E6.
CC   Transfected with: UniProtKB; P03129; Human papillomavirus type 16 protein E7.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 333760; Human papillomavirus type 16 (HPV16).
CC   Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   35Y
CA   Transformed cell line
DT   Created: 22-08-17; Last updated: 05-10-23; Version: 10
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RX   PubMed=22467494; DOI=10.1210/en.2011-1810;
RA   Bayasula X., Iwase A., Kiyono T., Takikawa S., Goto M., Nakamura T.,
RA   Nagatomo Y., Nakahara T., Kotani T., Kobayashi H., Kondo M.,
RA   Manabe S., Kikkawa F.;
RT   "Establishment of a human nonluteinized granulosa cell line that
RT   transitions from the gonadotropin-independent to the
RT   gonadotropin-dependent status.";
RL   Endocrinology 153:2851-2860(2012).
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RX   PubMed=31079267; DOI=10.1007/s10815-019-01469-y;
RA   Shimizu K., Nakamura T., Bayasula X., Nakanishi N., Kasahara Y.,
RA   Nagai T., Murase T., Osuka S., Goto M., Iwase A., Kikkawa F.;
RT   "Molecular mechanism of FSHR expression induced by BMP15 in human
RT   granulosa cells.";
RL   J. Assist. Reprod. Genet. 36:1185-1194(2019).
//
RX   PubMed=34888112; DOI=10.1016/j.scib.2020.03.040;
RA   Lv X.-M., He C.-B., Huang C., Hua G.-H., Chen X.-C., Timm B.K.,
RA   Maclin V.M., Haggerty A.A., Aust S.K., Golden D.M., Dave B.J.,
RA   Tseng Y.-A., Chen L., Wang H.-B., Chen P.-C., Klinkebiel D.L.,
RA   Karpf A.R., Dong J.-X., Drapkin R.I., Rueda B.R., Davis J.S., Wang C.;
RT   "Reprogramming of ovarian granulosa cells by YAP1 leads to development
RT   of high-grade cancer with mesenchymal lineage and serous features.";
RL   Sci. Bull. 65:1281-1296(2020).
//